Long-term effect of a single dose of flunarizine in Huntington's disease

被引：2

作者：

Belfiore, G

Di Maio, L

Napolitano, G

Cella, S

Filla, A

De Michele, G

Campanella, G

机构：

[1] Univ Naples Federico II, Neurol Clin, Dept Neurol Sci, I-80131 Naples, Italy

[2] Osped Civile Vito Fazzi, Dept Neurol, Lecce, Italy

[3] Mediterranean Neurol Inst NEUROMED, Pozzilli, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 1998年 / 5卷 / 03期

关键词：

Huntington's disease; flunarizine therapy;

D O I：

10.1046/j.1468-1331.1998.530249.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a preliminary pilot study on the clinical efficacy of flunarizine (FNZ), a calcium-entry blocker that causes extrapyramidal side-effects, in 10 patients with Huntington's disease (HD). FNZ (20 mg) administered by the sublingual route resulted in a decrease in choreic movements and improved dexterity in performing several tests. These effects lasted for at least 7 days after a single dose. Therefore, FNZ seems to exert the same effect as a long-acting neuroleptic agent in our HD patients. (C) 1998 Lippincott-Raven Publishers.

引用

页码：249 / 253

页数：5

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