Prognostic factors for survival in patients with pT1 N+ or T2-3 N0 gastric cancer in Japan

被引：10
|
作者：
Tokunaga, M. [1 ]
Ito, S. [2 ]
Yoshikawa, T. [3 ]
Nunobe, S. [4 ]
Fukagawa, T. [5 ]
Misawa, K. [2 ]
Cho, H. [3 ]
Katai, H. [5 ]
Sano, T. [4 ]
Terashima, M. [1 ]
机构：
[1] Shizuoka Canc Ctr, Div Gastr Surg, 1007 Shimonagakubo, Nagaizumi, Shizuoka 4118777, Japan
[2] Aichi Canc Ctr Hosp, Dept Gastroenterol Surg, Nagoya, Aichi, Japan
[3] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan
[4] Ariake Hosp, Inst Canc, Dept Gastroenterol Surg, Tokyo, Japan
[5] Natl Canc Ctr, Dept Gastr Surg, Tokyo, Japan
来源：
BRITISH JOURNAL OF SURGERY | 2017年 / 104卷 / 07期
关键词：
NEOADJUVANT CHEMOTHERAPY; D2; GASTRECTOMY; SUBCLASSIFICATION; SURGERY; ADENOCARCINOMA; INVASION; IMPACT; S-1;
D O I：
10.1002/bjs.10509
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: The outcome for pT1 N+ or pT2-3 N0 gastric cancer is favourable, but some patients suffer from recurrent disease. The aim of this study was to identify prognostic factors in patients with pT1 N+ or pT2-3 N0 gastric cancer. Methods: This was a multicentre, retrospective cohort study. All patients with pT1 N+ or pT2-3 N0 gastric cancer who underwent curative gastrectomy at five high-volume, specialized cancer centres in Japan between 2000 and 2008 were included. Demographic, clinical, surgical and pathological data were collected. Independent prognostic factors were identified using a Cox proportional hazards regression model. Results: Some 1442 patients were included. The 5-year overall survival rate for patients with pT1 N+ or pT2-3 N0 gastric cancer was 92.0 per cent. Multivariable analysis for overall survival identified age (hazard ratio (HR) 2.67, 95 per cent c.i. 2.09 to 3.43), sex (HR 0.57, 0.39 to 0.83) and clinical tumour depth (cT) (HR 1.45, 1.06 to 1.98) as independent prognostic factors. Conclusion: Survival of patients with pT1 N+ or pT2-3 N0 gastric cancer is good. Age 65 years or above, male sex and cT2-4 category are associated with worse overall survival.
引用
收藏
页码：885 / 890
页数：6
相关论文
共 50 条
  • [21] Endocavitary contact radiation therapy for ultrasonographically staged T1 N0 and T2 N0 rectal cancer
    Christoforidis, D.
    McNally, M. P.
    Jarosek, S. L.
    Madoff, R. D.
    Finne, C. O.
    [J]. BRITISH JOURNAL OF SURGERY, 2009, 96 (04) : 430 - 436
  • [22] Long-term results in patients with T2-3 N0 distal rectal cancer undergoing radiotherapy before transanal endoscopic microsurgery
    Lezoche, E
    Guerrieri, M
    Paganini, AM
    Baldarelli, M
    De Sanctis, A
    Lezoche, G
    [J]. BRITISH JOURNAL OF SURGERY, 2005, 92 (12) : 1546 - 1552
  • [23] Prognostic factors in T1 N0 M0 adenocarcinomas and bronchioloalveolar carcinomas of the lung
    Goldstein, NS
    Mani, A
    Chmielewski, G
    Welsh, R
    Pursel, S
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1999, 112 (03) : 391 - 402
  • [24] Is dissection of level IV necessary in patients with T1-T3 N0 tongue cancer?
    Khafif, A
    Lopez-Garza, JR
    Medina, JE
    [J]. LARYNGOSCOPE, 2001, 111 (06): : 1088 - 1090
  • [25] pT3 N0 Laryngeal Squamous Cell Carcinoma: Oncologic Outcomes and Prognostic Factors of Surgically Treated Patients
    Mattioli, Francesco
    Fermi, Matteo
    Molinari, Giulia
    Capriotti, Vincenzo
    Melegari, Gabriele
    Bertolini, Federica
    D'Angelo, Elisa
    Tirelli, Giancarlo
    Presutti, Livio
    [J]. LARYNGOSCOPE, 2021, 131 (10): : 2262 - 2268
  • [26] Clinicopathological features of pT1N2 and T1N3 gastric cancer
    Kim, Sungsoo
    Lai, Ji Fu
    Choi, Won Hyuck
    Hyung, Woo Jin
    Choi, Seung Ho
    Noh, Sung Hoon
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 : A146 - A146
  • [27] Prognostic factors in stage T1 N0 M0 adenocarcinomas and bronchioloalveolar adenocarcinomas of lung
    Mani, A
    Goldstein, N
    Chmielewski, G
    Welsh, R
    Pursel, S
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1999, 112 (04) : 541 - 541
  • [28] Factors predicting upstaging from clinical N0 to pN2a/N3a in breast cancer patients
    Oda, Goshi
    Nakagawa, Tsuyoshi
    Mori, Hiroki
    Onishi, Iichiro
    Fujioka, Tomoyuki
    Mori, Mio
    Kubota, Kazunori
    Hanazawa, Ryoichi
    Hirakawa, Akihiro
    Ishikawa, Toshiaki
    Okamoto, Kentaro
    Uetakesszsz, Hiroyuki
    [J]. WORLD JOURNAL OF CLINICAL ONCOLOGY, 2022, 13 (09): : 748 - 757
  • [29] Oncological outcomes in patients with pT1N0-3 or pT2-3N0 gastric cancer after curative resection without adjuvant chemotherapy
    Yagi, Shusuke
    Nunobe, Souya
    Makuuchi, Rie
    Ida, Satoshi
    Kumagai, Koshi
    Ohashi, Manabu
    Sano, Takeshi
    [J]. LANGENBECKS ARCHIVES OF SURGERY, 2021, 406 (02) : 419 - 426
  • [30] Expression of PDL-1 and tumour associated macrophages in penile cancer: N0 vs. N+
    Azhar, F.
    Sachdeva, A.
    Hart, C. A.
    Oliveira, P.
    Brown, M. D.
    Lau, M. W.
    Parnham, A. S.
    Sangar, V. K.
    Clarke, N. W.
    [J]. EUROPEAN UROLOGY, 2023, 83 : S893 - S893
12345