Electrosprayed core-shell microspheres for protein delivery

被引：29
|
作者：
Wu, Yiquan [1 ,3 ,4 ]
Liao, I-Chien [5 ]
Kennedy, Scott J. [3 ,4 ]
Du, Jinzhi [6 ,7 ]
Wang, Jun [6 ,7 ]
Leong, Kam W. [5 ]
Clark, Robert L. [2 ,3 ,4 ]
机构：
[1] Univ Rochester, Dept Mech Engn, Mat Sci Program, Rochester, NY 14627 USA
[2] Univ Rochester, Dept Biomed Engn, Rochester, NY 14627 USA
[3] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA
[4] Duke Univ, Ctr Biologically Inspired Mat & Mat Syst, Durham, NC 27708 USA
[5] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[6] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
[7] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 26期
关键词：
DRUG-DELIVERY; ELECTROHYDRODYNAMIC ATOMIZATION; BIOMEDICAL APPLICATIONS; POLYMER MICROSPHERES; POLY(VINYL ALCOHOL); DYNAMIC ATOMIZATION; DIBLOCK COPOLYMER; IN-VITRO; NANOPARTICLES; FABRICATION;
D O I：
10.1039/c0cc00535e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This communication describes a single-step electrospraying technique that generates core-shell microspheres (CSMs) with encapsulated protein as the core and an amphiphilic biodegradable polymer as the shell. The protein release profiles of the electro-sprayed CSMs showed steady release kinetics over 3 weeks without a significant initial burst.
引用
收藏
页码：4743 / 4745
页数：3
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