Electrosprayed core-shell microspheres for protein delivery

被引：29

作者：

Wu, Yiquan ^{[1
,3
,4
]}

Liao, I-Chien ^{[5
]}

Kennedy, Scott J. ^{[3
,4
]}

Du, Jinzhi ^{[6
,7
]}

Wang, Jun ^{[6
,7
]}

Leong, Kam W. ^{[5
]}

Clark, Robert L. ^{[2
,3
,4
]}

机构：

[1] Univ Rochester, Dept Mech Engn, Mat Sci Program, Rochester, NY 14627 USA

[2] Univ Rochester, Dept Biomed Engn, Rochester, NY 14627 USA

[3] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA

[4] Duke Univ, Ctr Biologically Inspired Mat & Mat Syst, Durham, NC 27708 USA

[5] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[6] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[7] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 26期

关键词：

DRUG-DELIVERY; ELECTROHYDRODYNAMIC ATOMIZATION; BIOMEDICAL APPLICATIONS; POLYMER MICROSPHERES; POLY(VINYL ALCOHOL); DYNAMIC ATOMIZATION; DIBLOCK COPOLYMER; IN-VITRO; NANOPARTICLES; FABRICATION;

D O I：

10.1039/c0cc00535e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication describes a single-step electrospraying technique that generates core-shell microspheres (CSMs) with encapsulated protein as the core and an amphiphilic biodegradable polymer as the shell. The protein release profiles of the electro-sprayed CSMs showed steady release kinetics over 3 weeks without a significant initial burst.

引用

页码：4743 / 4745

页数：3

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