Hemolytic steroid disulfates from the far eastern starfish Pteraster pulvillus

被引：18
|
作者：
Ivanchina, NV [1 ]
Kicha, AA [1 ]
Kalinovsky, AI [1 ]
Dmitrenok, PS [1 ]
Stonik, VA [1 ]
机构：
[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Branch, Vladivostok 22, Russia
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 02期
关键词：
D O I：
10.1021/np010650w
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six steroidal ophiuroid-type disulfates, namely, disodium. salts of (20R)-cholest-5-ene-3alpha,4beta,21-triol 3, 21-disulfate (1), (20R)-5alpha-cholestane-3alpha,4beta,21-triol 3,21-disulfate (2), (20R)-5alpha-cholestane-2beta,3alpha,21-triol 3,21-disulfate (3), and (20R)-5alpha-cholestane-3alpha,21-diol 3,21-disulfate (4), the dityrammonium salt of (20R)5alpha-cholestane-3alpha,21-diol 3,21-disulfate (5), and a mixture of sodium and tyrammonium salts (1:1) of (20R)cholest-5-ene-3alpha,21-diol 3,21-disulfate (6), have been isolated from the ethanolic extracts of Far Eastern starfish Pteraster pulvillus. Steroids 2 and 3 are new compounds. Steroids 1, 2, and 4-6 showed hemolytic activity to mouse erythrocytes with HC50 values of 8.0 x 10(-5), 4.5 x 10(-5), 1.0 x 10(-5), 1.8 x 10(-5), and 3.3 x 10(-5) M, respectively.
引用
收藏
页码：298 / 301
页数：4
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