Hemolytic steroid disulfates from the far eastern starfish Pteraster pulvillus

被引：18

作者：

Ivanchina, NV ^{[1
]}

Kicha, AA ^{[1
]}

Kalinovsky, AI ^{[1
]}

Dmitrenok, PS ^{[1
]}

Stonik, VA ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Branch, Vladivostok 22, Russia

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 02期

关键词：

D O I：

10.1021/np010650w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six steroidal ophiuroid-type disulfates, namely, disodium. salts of (20R)-cholest-5-ene-3alpha,4beta,21-triol 3, 21-disulfate (1), (20R)-5alpha-cholestane-3alpha,4beta,21-triol 3,21-disulfate (2), (20R)-5alpha-cholestane-2beta,3alpha,21-triol 3,21-disulfate (3), and (20R)-5alpha-cholestane-3alpha,21-diol 3,21-disulfate (4), the dityrammonium salt of (20R)5alpha-cholestane-3alpha,21-diol 3,21-disulfate (5), and a mixture of sodium and tyrammonium salts (1:1) of (20R)cholest-5-ene-3alpha,21-diol 3,21-disulfate (6), have been isolated from the ethanolic extracts of Far Eastern starfish Pteraster pulvillus. Steroids 2 and 3 are new compounds. Steroids 1, 2, and 4-6 showed hemolytic activity to mouse erythrocytes with HC50 values of 8.0 x 10(-5), 4.5 x 10(-5), 1.0 x 10(-5), 1.8 x 10(-5), and 3.3 x 10(-5) M, respectively.

引用

页码：298 / 301

页数：4

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