Ten-Year Retrospective of the Vanderbilt Institute of Chemical Biology Chemical Synthesis Core

被引:0
|
作者
Kim, Kwangho [1 ,2 ]
Christov, Plamen P. [1 ]
Romaine, Ian [1 ]
Tian, Jianhua [1 ]
Jana, Somnath [1 ]
Lamers, Alexander P. [1 ]
Dutter, Brendan F. [1 ]
Scaggs, Toya [1 ]
Jeon, Kyouk [1 ]
Guttentag, Benjamin [1 ]
Weaver, C. David [1 ,2 ,3 ]
Lindsley, Craig W. [1 ,2 ,3 ,4 ,5 ]
Waterson, Alex G. [1 ,2 ,3 ]
Sulikowski, Gary A. [1 ,2 ,3 ]
机构
[1] Vanderbilt Univ, Vanderbilt Inst Chem Biol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA
[3] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA
[5] Vanderbilt Univ, Warren Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA
关键词
POTASSIUM CHANNEL; RESISTANCE; REVEALS; ASSAY; PET; BACILLITHIOL; INHIBITORS; MODULATORS; DISCOVERY; PROBES;
D O I
10.1021/acschembio.0c00818
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chemical synthesis has been described as a central science. Its practice provides access to the chemical structures of known and/or designed function. In particular, human health is greatly impacted by synthesis that enables advancements in both basic science discoveries in chemical biology as well as translational research that can lead to new therapeutics. To support the chemical synthesis needs of investigators across campus, the Vanderbilt Institute of Chemical Biology established a chemical synthesis core as part of its foundation in 2008. Provided in this Review are examples of synthetic products, known and designed, produced in the core over the past 10 years.
引用
收藏
页码:787 / 793
页数:7
相关论文
共 50 条
  • [31] Refractive results of radial keratotomy: a ten-year retrospective study
    Salamon, SA
    Hjortdal, JO
    Ehlers, N
    ACTA OPHTHALMOLOGICA SCANDINAVICA, 2000, 78 (05): : 566 - 568
  • [32] Closing the saturation gap: a ten-year retrospective experience with methemoglobinemia
    Sahu, Kamal Kant
    Mishra, Ajay Kumar
    Lal, Amos
    George, Susan V.
    Siddiqui, Ahmad Daniyal
    INTERNAL AND EMERGENCY MEDICINE, 2020, 15 (06) : 1109 - 1112
  • [33] A TEN-YEAR RETROSPECTIVE REVIEW OF OUR BURN UNIT PATIENTS
    Sakrak, Tamer
    Kose, A. Aydan
    Karabagli, Yakup
    Cetin, Cengiz
    TURKISH JOURNAL OF PLASTIC SURGERY, 2010, 18 (03): : 111 - 115
  • [34] Pediatric trauma caused by personal watercraft: A ten-year retrospective
    Rubin, LE
    Stein, PB
    DiScala, C
    Grottkau, BE
    JOURNAL OF PEDIATRIC SURGERY, 2003, 38 (10) : 1525 - 1529
  • [35] Nontuberculous mycobacterial cervical adenitis: A ten-year retrospective review
    Panesar, J
    Higgins, K
    Daya, H
    Forte, V
    Allen, U
    LARYNGOSCOPE, 2003, 113 (01): : 149 - 154
  • [36] Surgical repair of vesicovaginal fistulae - A ten-year retrospective study
    Langkilde, NC
    Pless, TK
    Lundbeck, F
    Nerstrom, B
    SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 1999, 33 (02): : 100 - 103
  • [37] Trends in Mobile Computing within the IS Discipline: A Ten-Year Retrospective
    Ladd, D. Alan
    Datta, Avimanyu
    Sarker, Saonee
    Yu, Yanjun
    COMMUNICATIONS OF THE ASSOCIATION FOR INFORMATION SYSTEMS, 2010, 27 : 285 - 306
  • [38] A Profile of Visually Impaired Children: A Ten-Year Retrospective Study
    Okasheh-Otoom, Areej
    Gammoh, Yazan
    INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD, 2023, 11 (05): : 17685 - 17697
  • [39] A Ten-Year Retrospective Study on Livedo Vasculopathy in Asian Patients
    Gan, Emily Y.
    Tang, Mark B. Y.
    Tan, Suat Hoon
    Chua, Sze Hon
    Tan, Audrey W. H.
    ANNALS ACADEMY OF MEDICINE SINGAPORE, 2012, 41 (09) : 400 - 406
  • [40] Ten-year retrospective study on mandibular fractures in central Taiwan
    Chen, Yi-Tzu
    Chiu, Yu-Wei
    Chang, Yu-Chao
    Lin, Chiao-Wen
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2020, 48 (07)