Ten-Year Retrospective of the Vanderbilt Institute of Chemical Biology Chemical Synthesis Core

被引：0

作者：

Kim, Kwangho ^{[1
,2
]}

Christov, Plamen P. ^{[1
]}

Romaine, Ian ^{[1
]}

Tian, Jianhua ^{[1
]}

Jana, Somnath ^{[1
]}

Lamers, Alexander P. ^{[1
]}

Dutter, Brendan F. ^{[1
]}

Scaggs, Toya ^{[1
]}

Jeon, Kyouk ^{[1
]}

Guttentag, Benjamin ^{[1
]}

Weaver, C. David ^{[1
,2
,3
]}

Lindsley, Craig W. ^{[1
,2
,3
,4
,5
]}

Waterson, Alex G. ^{[1
,2
,3
]}

Sulikowski, Gary A. ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ, Vanderbilt Inst Chem Biol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

[3] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

[5] Vanderbilt Univ, Warren Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA

来源：

ACS CHEMICAL BIOLOGY | 2021年 / 16卷 / 05期

关键词：

POTASSIUM CHANNEL; RESISTANCE; REVEALS; ASSAY; PET; BACILLITHIOL; INHIBITORS; MODULATORS; DISCOVERY; PROBES;

D O I：

10.1021/acschembio.0c00818

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical synthesis has been described as a central science. Its practice provides access to the chemical structures of known and/or designed function. In particular, human health is greatly impacted by synthesis that enables advancements in both basic science discoveries in chemical biology as well as translational research that can lead to new therapeutics. To support the chemical synthesis needs of investigators across campus, the Vanderbilt Institute of Chemical Biology established a chemical synthesis core as part of its foundation in 2008. Provided in this Review are examples of synthetic products, known and designed, produced in the core over the past 10 years.

引用

页码：787 / 793

页数：7

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