Inhibitory effect of TRK-530 on inflammatory cytokines in bone marrow of rats with adjuvant arthritis

被引：11
|
作者：
Tanahashi, M [1 ]
Koike, J [1 ]
Kawabe, N [1 ]
Nakadate-Matsushita, T [1 ]
机构：
[1] Toray Ind Inc, Basic Res Labs, Kanagawa 248, Japan
来源：
PHARMACOLOGY | 1998年 / 56卷 / 05期
关键词：
TRK-530; bisphosphonate; adjuvant arthritis; cytokine-induced neutrophil chemoattractant-1; tumor necrosis factor alpha;
D O I：
10.1159/000028203
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
TRK-530 is a novel synthetic bisphosphonate compound which exhibits inhibitory activity in the rat adjuvant arthritis (AA) model. We found that, during AA development, the concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and tumor necrosis factor alpha (TNF-alpha) in the bone marrow increased, and that administration of TRK-530 decreased the concentrations of these cytokines. The suppression of these concentration increases paralleled the inhibition of paw edema, Paw edema inhibition by TRK-530 in rat AA may be the result of decreasing CINC-1 and TNF-alpha concentrations.
引用
收藏
页码：237 / 241
页数：5
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