Cutting edge:: OX40 inhibits TGF-β- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells

被引：167

作者：

So, Takanori ^{[1
]}

Croft, Michael ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Mol Immunol, La Jolla, CA 92037 USA

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 179卷 / 03期

关键词：

D O I：

10.4049/jimmunol.179.3.1427

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-beta R promote Foxp3 expression in activated naive CD25(-) CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-beta-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 Tcells into CD25(+)Foxp3(+) T cells. These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3(+) regulatory T cells.

引用

页码：1427 / 1430

页数：4

共 50 条

[31] Induction of antigen specific CD4+CD25+Foxp3+T regulatory cells from naive natural thymic derived T regulatory cells
Hall, Bruce M.
Tran, Giang T.
Robinson, Catherine M.
Hodgkinson, Suzanne J.
INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 28 (02) : 875 - 886
[32] Conversion of naive CD4+CD25-T cells to anergic-suppressor T cells by co-culture with CD4+CD25+T cells
Qiao, M
Shevach, EM
FASEB JOURNAL, 2005, 19 (04): : A337 - A337
[33] Ox40 ligation enhances clonal expansion and effector functions of CD4 T cells.
Gramaglia, I
Weinberg, AD
Croft, M
FASEB JOURNAL, 1999, 13 (05): : A949 - A949
[34] Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25-Foxp3+ T cells
Polanczyk, Magdalena J.
Walker, Edwin
Haley, Daniel
Guerrouahen, Bella S.
Akporiaye, Emmanuel T.
JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (1)
[35] Antigen presentation to naive CD4 T cells in the lymph node
Itano, AA
Jenkins, MK
NATURE IMMUNOLOGY, 2003, 4 (08) : 733 - 739
[36] Antigen presentation to naive CD4 T cells in the lymph node
Andrea A Itano
Marc K Jenkins
Nature Immunology, 2003, 4 : 733 - 739
[37] CD4+CD25+ T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen
Watanabe, T
Tamori, M
Kita, T
Chiba, T
Wakatsuki, Y
INFLAMMATORY BOWEL DISEASES, 2005, 11 (06) : 541 - 550
[38] Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells
Benkhoucha, Mahdia
Santiago-Raber, Marie-Laure
Schneiter, Gregory
Chofflon, Michel
Funakoshi, Hiroshi
Nakamura, Toshikazu
Lalive, Patrice H.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) : 6424 - 6429
[39] Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity:: a novel regulatory role for OX40 and its comparison with GITR
Valzasina, B
Guiducci, C
Dislich, H
Killeen, N
Weinberg, AD
Colombo, MP
BLOOD, 2005, 105 (07) : 2845 - 2851
[40] In vivo conversion of CD4+25- naive T cells to CD4+25+ regulatory T cells by pancreatic adenocarcinoma
Moo-Young, TA
Moore, TT
Liyanage, UK
Eberlein, TJ
Goedegebuure, PS
Linehan, DC
ANNALS OF SURGICAL ONCOLOGY, 2005, 12 (02) : S9 - S9

← 1 2 3 4 5 →