Cutting edge:: OX40 inhibits TGF-β- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells

被引：167

作者：

So, Takanori ^{[1
]}

Croft, Michael ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Mol Immunol, La Jolla, CA 92037 USA

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 179卷 / 03期

关键词：

D O I：

10.4049/jimmunol.179.3.1427

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-beta R promote Foxp3 expression in activated naive CD25(-) CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-beta-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 Tcells into CD25(+)Foxp3(+) T cells. These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3(+) regulatory T cells.

引用

页码：1427 / 1430

页数：4

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