MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine

被引：18

作者：

Sato, Akira ^{[1
,2
,3
,4
]}

Omi, Takuya ^{[4
]}

Yamamoto, Akihiro ^{[4
]}

Satake, Akito ^{[4
]}

Hiramoto, Akiko ^{[4
]}

Masutani, Mitsuko ^{[2
,3
,5
]}

Tanuma, Sei-ichi ^{[1
]}

Wataya, Yusuke ^{[4
]}

Kim, Hye-Sook ^{[4
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Biochem, Noda, Chiba 278, Japan

[2] Natl Canc Ctr, Div Genome Stabil Res, Chuo Ku, Tokyo, Japan

[3] Natl Canc Ctr, Div Chemotherapy & Clin Res, Chuo Ku, Tokyo, Japan

[4] Okayama Univ, Fac Pharmaceut Sci, Dept Drug Informat, Kita Ku, Okayama 700, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Dept Frontier Life Sci, Nagasaki 852, Japan

来源：

PLOS ONE | 2016年 / 11卷 / 04期

关键词：

DEOXYRIBONUCLEOSIDE-TRIPHOSPHATE IMBALANCE; DOUBLE STRAND BREAKS; MOUSE FM3A CELLS; DNTP IMBALANCE; MESSENGER-RNAS; LAMIN B1; MECHANISM; 5-FLUORO-2'-DEOXYURIDINE; MODULATION; PROLIFERATION;

D O I：

10.1371/journal.pone.0153130

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell-death can be necrosis and apoptosis. We are investigating the mechanisms regulating the cell death that occurs on treatment of mouse cancer cell-line FM3A with antitumor 5-fluoro-2'-deoxyuridine (FUdR): necrosis occurs for the original clone F28-7, and apoptosis for its variant F28-7-A. Here we report that a microRNA (miR-351) regulates the cell death pattern. The miR-351 is expressed strongly in F28-7-A but only weakly in F28-7. Induction of a higher expression of miR-351 in F28-7 by transfecting an miRNA mimic into F28-7 resulted in a change of the death mode; necrosis to apoptosis. Furthermore, transfection of an miR-351 inhibitor into F28-7-A resulted in the morphology change, apoptosis to necrosis, in this death-by-FUdR. Possible mechanism involving lamin B1 in this miR-351's regulatory action is discussed.

引用

页数：13

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