MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine

被引：18

作者：

Sato, Akira ^{[1
,2
,3
,4
]}

Omi, Takuya ^{[4
]}

Yamamoto, Akihiro ^{[4
]}

Satake, Akito ^{[4
]}

Hiramoto, Akiko ^{[4
]}

Masutani, Mitsuko ^{[2
,3
,5
]}

Tanuma, Sei-ichi ^{[1
]}

Wataya, Yusuke ^{[4
]}

Kim, Hye-Sook ^{[4
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Biochem, Noda, Chiba 278, Japan

[2] Natl Canc Ctr, Div Genome Stabil Res, Chuo Ku, Tokyo, Japan

[3] Natl Canc Ctr, Div Chemotherapy & Clin Res, Chuo Ku, Tokyo, Japan

[4] Okayama Univ, Fac Pharmaceut Sci, Dept Drug Informat, Kita Ku, Okayama 700, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Dept Frontier Life Sci, Nagasaki 852, Japan

来源：

PLOS ONE | 2016年 / 11卷 / 04期

关键词：

DEOXYRIBONUCLEOSIDE-TRIPHOSPHATE IMBALANCE; DOUBLE STRAND BREAKS; MOUSE FM3A CELLS; DNTP IMBALANCE; MESSENGER-RNAS; LAMIN B1; MECHANISM; 5-FLUORO-2'-DEOXYURIDINE; MODULATION; PROLIFERATION;

D O I：

10.1371/journal.pone.0153130

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell-death can be necrosis and apoptosis. We are investigating the mechanisms regulating the cell death that occurs on treatment of mouse cancer cell-line FM3A with antitumor 5-fluoro-2'-deoxyuridine (FUdR): necrosis occurs for the original clone F28-7, and apoptosis for its variant F28-7-A. Here we report that a microRNA (miR-351) regulates the cell death pattern. The miR-351 is expressed strongly in F28-7-A but only weakly in F28-7. Induction of a higher expression of miR-351 in F28-7 by transfecting an miRNA mimic into F28-7 resulted in a change of the death mode; necrosis to apoptosis. Furthermore, transfection of an miR-351 inhibitor into F28-7-A resulted in the morphology change, apoptosis to necrosis, in this death-by-FUdR. Possible mechanism involving lamin B1 in this miR-351's regulatory action is discussed.

引用

页数：13

共 50 条

[21] GROWTH INHIBITION OF A HUMAN TUMOR CELL STRAIN BY 5-FLUORO-2'-DEOXYURIDINE - TIME PARAMETERS FOR SUBSEQUENT REVERSAL BY THYMIDINE
EIDINOFF, ML
RICH, MA
CANCER RESEARCH, 1959, 19 (05) : 521 - 524
[22] ENHANCEMENT OF 5-FLUORO-2'-DEOXYURIDINE ANTINEOPLASTIC ACTIVITY BY 5-BENZYLOXYBENZYLOXYBENZYLACYCLOURIDINE IN A HUMAN COLON-CARCINOMA CELL-LINE
CHU, E
CHU, MY
DARNOWSKI, JW
CHEN, ZH
PAN, BC
CHU, SH
CANCER RESEARCH, 1992, 52 (07) : 1729 - 1736
[23] Activation of c-jun and c-fos genes in dNTP imbalance cell death induced with 5-fluoro-2′-deoxyuridine in mouse mammary tumor FM3A cell line
Kakutani, T
Ebara, Y
Kanja, K
Takahashi, K
Wataya, Y
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1998, 17 (08): : 1299 - 1308
[24] GROWTH INHIBITION OF A HUMAN TUMOR CELL STRAIN BY 5-FLUOROURACIL, 5-FLUOROURIDINE, AND 5-FLUORO-2'-DEOXYURIDINE-REVERSAL STUDIES
RICH, MA
BOLAFFI, JL
KNOLL, JE
CHEONG, L
EIDINOFF, ML
CANCER RESEARCH, 1958, 18 (06) : 730 - 735
[25] 5-FLUOROURACIL AND 5-FLUORO-2'-DEOXYURIDINE FOLLOW DIFFERENT METABOLIC PATHWAYS IN THE INDUCTION OF CELL LETHALITY IN L1210-LEUKEMIA
ROOBOL, C
DEDOBBELEER, GBE
BERNHEIM, JL
BRITISH JOURNAL OF CANCER, 1984, 49 (06) : 739 - 744
[26] Extracellular Leakage Protein Patterns in Two Types of Cancer Cell Death: Necrosis and Apoptosis
Sato, Akira
Shimotsuma, Akira
Miyoshi, Tetsuya
Takahashi, Yui
Funayama, Naoki
Ogino, Yoko
Hiramoto, Akiko
Wataya, Yusuke
Kim, Hye-Sook
ACS OMEGA, 2023, 8 (28): : 25059 - 25065
[27] MODULATION OF 5-FLUORO-2'-DEOXYURIDINE RESPONSE BY FOLINIC ACID IN HUMAN COLONIC TUMOR-CELL LINES - THE ROLE OF THYMIDYLATE SYNTHASE
DAVIS, ST
BERGER, SH
MOLECULAR PHARMACOLOGY, 1989, 35 (04) : 422 - 427
[28] Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-20-deoxyuridine
Sato, Akira
Nakama, Kentaro
Watanabe, Hiroki
Satake, Akito
Yamamoto, Akihiro
Omi, Takuya
Hiramoto, Akiko
Masutani, Mitsuko
Wataya, Yusuke
Kim, Hye-Sook
FEBS JOURNAL, 2014, 281 (07) : 1892 - 1900
[29] Novel Anticancer Strategy Targeting Switch Mechanisms in Two Types of Cell Death: Necrosis and Apoptosis
Sato, Akira
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2017, 137 (11): : 1315 - 1321
[30] PHENOTYPIC DRIFT AND HETEROGENEITY IN RESPONSE OF METASTATIC MAMMARY ADENOCARCINOMA CELL CLONES TO ADRIAMYCIN, 5-FLUORO-2'-DEOXYURIDINE AND METHOTREXATE TREATMENT INVITRO
WELCH, DR
NICOLSON, GL
CLINICAL & EXPERIMENTAL METASTASIS, 1983, 1 (04) : 317 - 325

← 1 2 3 4 5 →