Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?

被引：8
|
作者：
Bozkurt, Huseyin Sancar [1 ]
Quigley, Eamonn M. M. [2 ,3 ]
机构：
[1] Maltepe Univ, Med Fac Internal Med, Clin Gastroenterol, TR-34843 Maltepe, Turkey
[2] Houston Methodist Hosp, Lynda K & David M Underwood Ctr Digest Disorders, Gastroenterol & Hepatol, Houston, TX 77062 USA
[3] Weill Cornell Med Coll, Houston, TX 77062 USA
来源：
GASTROINTESTINAL DISORDERS | 2019年 / 1卷 / 02期
关键词：
Bifidobacterium; MAIT cells; colorectal cancer;
D O I：
10.3390/gidisord1020022
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. Impairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment.
引用
收藏
页码：266 / 272
页数：7
相关论文
共 50 条
  • [41] Defining a Protective Role for Mucosal-associated Invariant T (MAIT) Cells in Spontaneous Cutaneous Lupus Erythematosus
    Crossland, Grace
    Mendyka, Lindsay
    Constantinides, Michael
    Skopelja-Gardner, Sladjana
    ARTHRITIS & RHEUMATOLOGY, 2024, 76 : 1840 - 1842
  • [42] Mucosal-associated invariant T (MAIT) cells, a new source of universal immune cells for chimeric antigen receptor (CAR)-cell therapy
    Bohineust, Armelle
    Tourret, Marie
    Derivry, Lucille
    Caillat-Zucman, Sophie
    BULLETIN DU CANCER, 2021, 108 (10) : S92 - S95
  • [43] Antimicrobial activity of mucosal-associated invariant T cells
    Lionel Le Bourhis
    Emmanuel Martin
    Isabelle Péguillet
    Amélie Guihot
    Nathalie Froux
    Maxime Coré
    Eva Lévy
    Mathilde Dusseaux
    Vanina Meyssonnier
    Virginie Premel
    Charlotte Ngo
    Béatrice Riteau
    Livine Duban
    Delphine Robert
    Shouxiong Huang
    Martin Rottman
    Claire Soudais
    Olivier Lantz
    Nature Immunology, 2010, 11 : 701 - 708
  • [44] Mucosal-Associated Invariant T Cells in Regenerative Medicine
    Wakao, Hiroshi
    Sugimoto, Chie
    Kimura, Shinzo
    Wakao, Rika
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [45] Mucosal-associated invariant T cells in clinical diseases
    Reantragoon, Rangsima
    Boonpattanaporn, Norasate
    Corbett, Alexandra Jane
    McCluskey, James
    ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2016, 34 (01): : 3 - 10
  • [46] Antimicrobial activity of mucosal-associated invariant T cells
    Le Bourhis, Lionel
    Martin, Emmanuel
    Peguillet, Isabelle
    Guihot, Amelie
    Froux, Nathalie
    Core, Maxime
    Levy, Eva
    Dusseaux, Mathilde
    Meyssonnier, Vanina
    Premel, Virginie
    Ngo, Charlotte
    Riteau, Beatrice
    Duban, Livine
    Robert, Delphine
    Rottman, Martin
    Soudais, Claire
    Lantz, Olivier
    NATURE IMMUNOLOGY, 2010, 11 (08) : 701 - U66
  • [47] Mucosal-Associated invariant T Cells in Autoimmune Diseases
    Chiba, Asako
    Murayama, Goh
    Miyake, Sachiko
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [48] Reduction in mucosal-associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN-γ concentration
    Hetemaki, Iivo
    Sarkkinen, Joona
    Wong, Huai Hui
    Heikkila, Nelli
    Laakso, Saila
    Miettinen, Simo
    Mayranpaa, Mikko I.
    Makitie, Outi
    Arstila, T. Petteri
    Kekalainen, Eliisa
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024,
  • [49] How MR1 Presents a Pathogen Metabolic Signature to Mucosal-Associated Invariant T (MAIT) Cells
    McWilliam, Hamish E. G.
    Villadangos, Jose A.
    TRENDS IN IMMUNOLOGY, 2017, 38 (09) : 679 - 689
  • [50] Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma
    Lezmi, Guillaume
    Abou Taam, Rola
    Dietrich, Celine
    Chatenoud, Lucienne
    de Blic, Jacques
    Leite-de-Moraes, Maria
    CLINICAL IMMUNOLOGY, 2018, 188 : 7 - 11
12345