Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?

被引：8
|
作者：
Bozkurt, Huseyin Sancar [1 ]
Quigley, Eamonn M. M. [2 ,3 ]
机构：
[1] Maltepe Univ, Med Fac Internal Med, Clin Gastroenterol, TR-34843 Maltepe, Turkey
[2] Houston Methodist Hosp, Lynda K & David M Underwood Ctr Digest Disorders, Gastroenterol & Hepatol, Houston, TX 77062 USA
[3] Weill Cornell Med Coll, Houston, TX 77062 USA
来源：
GASTROINTESTINAL DISORDERS | 2019年 / 1卷 / 02期
关键词：
Bifidobacterium; MAIT cells; colorectal cancer;
D O I：
10.3390/gidisord1020022
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. Impairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment.
引用
收藏
页码：266 / 272
页数：7
相关论文
共 50 条
  • [11] Mucosal-associated invariant T (MAIT) cells: What are they and what are they doing in skin?
    Li, J.
    Reantragoon, R.
    Kostenko, L.
    Corbett, A. J.
    Varigos, G.
    Carbone, F. R.
    AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2016, 57 : 7 - 7
  • [12] Mucosal-associated invariant T cells for cancer immunotherapy
    Li, Yan-Ruide
    Zhou, Kuangyi
    Wilson, Matthew
    Kramer, Adam
    Zhu, Yichen
    Dawson, Niels
    Yang, Lili
    MOLECULAR THERAPY, 2023, 31 (03) : 631 - 646
  • [13] The association between mucosal-associated invariant T (MAIT) cells and acute ischemic stroke
    Nakajima, S.
    Tanaka, R.
    Yamashiro, K.
    Chiba, A.
    Noto, D.
    Miyamoto, N.
    Ueno, Y.
    Urabe, T.
    Miyake, S.
    Hattori, N.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 514 - 515
  • [14] Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis
    Trivedi, Shubhanshi
    Labuz, Daniel
    Anderson, Cole P.
    Araujo, Claudia, V
    Blair, Antoinette
    Middleton, Elizabeth A.
    Jensen, Owen
    Tran, Alexander
    Mulvey, Matthew A.
    Campbell, Robert A.
    Hale, J. Scott
    Rondina, Matthew T.
    Leung, Daniel T.
    ELIFE, 2020, 9 : 1 - 19
  • [15] Characterisation of Mucosal-Associated Invariant T (MAIT) Cells in Ankylosing Spondylitis Patients.
    Almaghlouth, Ibrahim
    Gracey, Eric
    Qaiyum, Zoya
    Inman, Robert D.
    Anton, Ammepa
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S265 - S265
  • [16] Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders
    Touch, Sothea
    Assmann, Karen E.
    Aron-Wisnewsky, Judith
    Marquet, Florian
    Rouault, Christine
    Fradet, Magali
    Mosbah, Helena
    Isnard, Richard
    Helft, Gerard
    Lehuen, Agnes
    Poitou, Christine
    Clement, Karine
    Andre, Sebastien
    FASEB JOURNAL, 2018, 32 (09): : 5078 - 5089
  • [17] Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases
    Serriari, N-E
    Eoche, M.
    Lamotte, L.
    Lion, J.
    Fumery, M.
    Marcelo, P.
    Chatelain, D.
    Barre, A.
    Nguyen-Khac, E.
    Lantz, O.
    Dupas, J-L
    Treiner, E.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 176 (02): : 266 - 274
  • [18] Circulating Mucosal-associated invariant T (MAIT) cells in Chronic Lymphocytic Leukemia (CLL)
    Alcantara, Marice
    Kannourakis, George
    Berzins, Stuart
    Wallace, Morgan
    Kelly, Jason
    LEUKEMIA & LYMPHOMA, 2017, 58 : 172 - 173
  • [19] Notch signaling regulates function of human mucosal-associated invariant T (MAIT) cells
    Sodsai, Pimpayao
    Klinchanhom, Siriwan
    Hirankarn, Nattiya
    Reantragoon, Rangsima
    Palaga, Tanapat
    ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2024, 42 (01): : 86 - 96
  • [20] Defining the role of mucosal-associated invariant T (MAIT) cells in B cell help
    Jensen, Owen
    Trivedi, Shubhanshi
    Meier, Jeremy D.
    Leung, Daniel T.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
12345