Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?

被引：8
|
作者：
Bozkurt, Huseyin Sancar [1 ]
Quigley, Eamonn M. M. [2 ,3 ]
机构：
[1] Maltepe Univ, Med Fac Internal Med, Clin Gastroenterol, TR-34843 Maltepe, Turkey
[2] Houston Methodist Hosp, Lynda K & David M Underwood Ctr Digest Disorders, Gastroenterol & Hepatol, Houston, TX 77062 USA
[3] Weill Cornell Med Coll, Houston, TX 77062 USA
来源：
GASTROINTESTINAL DISORDERS | 2019年 / 1卷 / 02期
关键词：
Bifidobacterium; MAIT cells; colorectal cancer;
D O I：
10.3390/gidisord1020022
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. Impairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment.
引用
收藏
页码：266 / 272
页数：7
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