Novel thiophenecarboxamide IKK-2 inhibitors

被引：3
|
作者：
不详
机构：
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2005年 / 15卷 / 03期
关键词：
asthma; chronic obstructive pulmonary disease (COPD); I kappa B kinase-2 (IKK-2); inflammation; rheumatoid arthritis; thiophene;
D O I：
10.1517/13543776.15.3.343
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two applications claim novel ureido 5-(2-aminoethoxyphenyl)thiophenecarboxamide derivatives that differ in the position of the attached alkoxy chain, either ortho or para, as I kappa B kinase-2 (IKK-2) inhibitors. Some of the compounds display low nanomolar potency, and the compounds are claimed to be useful in the treatment of asthma, rheumatoid arthritis and chronic obstructive pulmonary disease (COPD).
引用
收藏
页码：343 / 347
页数：5
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