Design, radio-synthesis and evaluation of a novel [18F]-TKP for noninvasive PET imaging of brain Aβ deposits and neurofibrillary tangles

被引：0
|
作者：
Kong, Yanyan [2 ]
Hua, Fengchun [2 ]
Guan, Yihui [2 ]
Zhao, Bizeng [1 ]
机构：
[1] Jiaotong Univ, Shanghai Peoples Hosp 6, Shanghai, Peoples R China
[2] Fudan Univ, Huashan Hosp, PET Ctr, Shanghai, Peoples R China
来源：
JOURNAL OF NUCLEAR MEDICINE | 2016年 / 57卷
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
1030
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles
    Michel Koole
    Talakad G. Lohith
    John L. Valentine
    Idriss Bennacef
    Ruben Declercq
    Tom Reynders
    Kerry Riffel
    Sofie Celen
    Kim Serdons
    Guy Bormans
    Sandrine Ferry-Martin
    Philippe Laroque
    Abbas Walji
    Eric D. Hostetler
    Richard J. Briscoe
    Jan de Hoon
    Cyrille Sur
    Koen Van Laere
    Arie Struyk
    Molecular Imaging and Biology, 2020, 22 : 173 - 180
  • [2] Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles
    Koole, Michel
    Lohith, Talakad G.
    Valentine, John L.
    Bennacef, Idriss
    Declercq, Ruben
    Reynders, Tom
    Riffel, Kerry
    Celen, Sofie
    Serdons, Kim
    Bormans, Guy
    Ferry-Martin, Sandrine
    Laroque, Philippe
    Walji, Abbas
    Hostetler, Eric D.
    Briscoe, Richard J.
    de Hoon, Jan
    Sur, Cyrille
    Van Laere, Koen
    Struyk, Arie
    MOLECULAR IMAGING AND BIOLOGY, 2020, 22 (01) : 173 - 180
  • [3] [18F]Tau911, a candidate for PET imaging of the THK site in neurofibrillary tangles
    Cai, Lisheng
    Qu, Baoxi
    Hurtle, Bryan
    Dadiboyena, Sureshbabu
    Morse, Cheryl
    Diaz-Arrastia, Ramon
    Innis, Robert
    Pike, Victor W.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2015, 58 : S211 - S211
  • [4] A simplified method for the radio-synthesis of [18F]-flumazenil
    Kumar, P.
    Joshi, R.
    Rao, N.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (SUPPL 1) : S729 - S729
  • [5] Development of [18F]FAZIN3 for PET imaging of neurofibrillary tangles in Alzheimer's Disease
    Liang, Christopher
    Phuc Lam
    Martinez, Stephanie
    Mukherjee, Jogeshwar
    JOURNAL OF NUCLEAR MEDICINE, 2020, 61
  • [6] cGMP production of the radiopharmaceutical [18F]MK-6240 for PET imaging of human neurofibrillary tangles
    Collier, Thomas Lee
    Yokell, Daniel L.
    Livni, Eli
    Rice, Peter A.
    Celen, Sofie
    Serdons, Kim
    Neelamegam, Ramesh
    Bormans, Guy
    Harris, Dawn
    Walji, Abbas
    Hostetler, Eric D.
    Bennacef, Idriss
    Vasdev, Neil
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2017, 60 (05): : 263 - 269
  • [7] Synthesis and preliminary PET imaging studies of [18F]MK-6240: A radiotracer for imaging neurofibrillary tangles (NFTs) in Alzheimer's Disease
    Walji, Abbas
    Bennacef, Idriss
    Stump, Craig
    Selnick, Harold
    Li, Jing
    Hostetler, Eric
    Mulhearn, James
    Zeng, Zhizhen
    Miller, Patricia
    Salinas, Cristian
    Connolly, Brett
    Gantert, Liza
    Holahan, Marie
    O'Malley, Stacey
    Purcell, Mona
    Riffel, Kerry
    Balsells, Jaume
    OBrien, Julie
    Soriano, Aileen
    Ogawa, Aimie
    Xu, Serena
    Joshi, Elizabeth
    Della Rocca, Joe
    Schachter, Joel
    Hesk, David
    Schenk, David
    Sur, Cyrille
    Struyk, Arie
    Babaoglu, Kerim
    Lohith, Talakad
    Wang, Yaode
    Fu, Jianmin
    Celen, Sofie
    Bormans, Guy
    Vandenbulcke, Mathieu
    Vandenberghe, Rik
    de Hoon, Jan
    Koole, Michel
    Van Laere, Koen
    Serdons, Kim
    Yang, Kun
    Evelhoch, Jeffrey
    Coleman, Paul
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [8] Radiosynthesis of [18F]gem-difluoroalkenes and [18F]CF3 Groups - Preparation of [18F]lansoprazole and related analogs for PET imaging of tau neurofibrillary tangles
    Brooks, Allen F.
    Rodnick, Melissa E.
    Fawaz, Maria V.
    Desmond, Timothy J.
    Scott, Peter J. H.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2013, 56 : S29 - S29
  • [9] Tau PET imaging: Discovery of [18F]MK-6240 for human in vivo quantification of neurofibrillary tangles (NFTs)
    Walji, Abbas
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [10] Evaluation of In Vivo and In Vitro Stability to Support the Preclinical and Clinical Development of [18F]MK-6240, a PET Tracer for Imaging Neurofibrillary Tangles
    Riffel, Kerry
    Bennacef, Idriss
    Holahan, Marie
    Haley, Hyking
    Gantert, Liza
    Purcell, Mona
    Struyk, Arie
    Sur, Cyrille
    Celen, Sophie
    Serdons, Kim
    van Laere, Koen
    Bormans, Guy
    Hostetler, Eric D.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2017, 60 : S373 - S373
12345