Enantioselective synthesis of (R)-2-methylalkanoic acids:: A convenient approach to α-substituted chiral carboxylic acid derivatives

被引：6

作者：

Shirali, S ^{[1
]}

Zhang, AJ ^{[1
]}

机构：

[1] USDA ARS, Chem Affecting Insect Behav Lab, Beltsville, MD 20705 USA

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 18期

关键词：

alkylation; chiral; enantioselctive; lithium hydroperoxide;

D O I：

10.1081/SCC-200030650

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemization-free deacylation of N-acylimidazolidine-2-ones using lithium hydroperoxide affords the corresponding a-substituted chiral carboxylic acids in high yield while permitting recovery of the chiral auxiliary.

引用

页码：3435 / 3441

页数：7

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