Convenient synthesis of N1-substituted orotic acid derivatives

被引：7
|
作者：
Bowler, Jeannette T. [1 ]
Clausen, Caitlin R. [1 ]
Blackburn, Daniel J. [1 ]
Wu, Weiming [1 ]
机构：
[1] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 47期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Orotic acid; Orotidine; Synthesis; Maleimide; Bromomaleimide; Dibromosuccinimide; 1,3-DIMETHYLOROTIC ACID; OROTIDINE-5'-MONOPHOSPHATE DECARBOXYLASE; MECHANISTIC IMPLICATIONS; PROFICIENT ENZYME; CARBANIONS; MALEIMIDES; STABILITY; ANALOGS; URACIL; MODEL;
D O I：
10.1016/j.tetlet.2014.10.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6465 / 6466
页数：2
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