Convenient synthesis of N1-substituted orotic acid derivatives

被引：7

作者：

Bowler, Jeannette T. ^{[1
]}

Clausen, Caitlin R. ^{[1
]}

Blackburn, Daniel J. ^{[1
]}

Wu, Weiming ^{[1
]}

机构：

[1] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 47期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Orotic acid; Orotidine; Synthesis; Maleimide; Bromomaleimide; Dibromosuccinimide; 1,3-DIMETHYLOROTIC ACID; OROTIDINE-5'-MONOPHOSPHATE DECARBOXYLASE; MECHANISTIC IMPLICATIONS; PROFICIENT ENZYME; CARBANIONS; MALEIMIDES; STABILITY; ANALOGS; URACIL; MODEL;

D O I：

10.1016/j.tetlet.2014.10.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6465 / 6466

页数：2

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