Selectivity of N-Aroyl-N′-arylthioureas towards 2-(1,3-Dioxo-1H-inden-2(3H)-ylidene)malononitrile. New Synthesis of (Z)-N-((E)-4-Amino-1-aryl-5-cyano-6-oxo-1H-indeno[1,2-d][1,3]-thiazepin-2(6H)-ylidene)-4-arylamides of Antitumor and Antioxidant Activities

The reaction between N-aroyl-M-arylthioureas with 2-(1,3-dioxoindan-2-ylidene)malononitrile furnished indeno[1,2d][1,3]thiazepines in 70-85% yields. The mechanism of the products' formation is discussed. Some of the products showed effective antitumor and antioxidant activities. The results revealed that compound indenothiazepine derivative showed a high inhibition of the cell growth of Hep-G2 cells is compared with the growth of untreated control cells, as concluded from their low 1050 value 21.73 mu M. On the other hand, two indenothiazepine derivatives have an effective antioxidant activity with SC(50) values of 62.5 mM and 87.4 mM, respectively.