Selectivity of N-Aroyl-N′-arylthioureas towards 2-(1,3-Dioxo-1H-inden-2(3H)-ylidene)malononitrile. New Synthesis of (Z)-N-((E)-4-Amino-1-aryl-5-cyano-6-oxo-1H-indeno[1,2-d][1,3]-thiazepin-2(6H)-ylidene)-4-arylamides of Antitumor and Antioxidant Activities

被引：10
|
作者：
Aly, Ashraf A. [1 ]
Brown, Alan B. [2 ]
Ramadan, Mohamed [3 ]
Abdel-Aziz, Mohamed [3 ]
Abuo-Rahma, Gamal El-Din A. A. [3 ]
Radwan, Mohamed F. [3 ]
Gamal-Eldeen, Amira M. [4 ]
机构：
[1] Menia Univ, Fac Sci, Dept Chem, El Minia 61519, Egypt
[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA
[3] Menia Univ, Fac Sci, Dept Med Chem, El Minia 61519, Egypt
[4] Natl Res Ctr, Dept Biochem, Div Genet Engn & Biotechnol, Giza, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 03期
关键词：
DERIVATIVES;
D O I：
10.1002/jhet.344
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction between N-aroyl-M-arylthioureas with 2-(1,3-dioxoindan-2-ylidene)malononitrile furnished indeno[1,2d][1,3]thiazepines in 70-85% yields. The mechanism of the products' formation is discussed. Some of the products showed effective antitumor and antioxidant activities. The results revealed that compound indenothiazepine derivative showed a high inhibition of the cell growth of Hep-G2 cells is compared with the growth of untreated control cells, as concluded from their low 1050 value 21.73 mu M. On the other hand, two indenothiazepine derivatives have an effective antioxidant activity with SC(50) values of 62.5 mM and 87.4 mM, respectively.
引用
收藏
页码：503 / 508
页数：6
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