Advances of MUC1 as a target for breast cancer immunotherapy

被引：1
|
作者：
Yang, E. [1 ]
Hu, X. F. [1 ]
Xing, P. X. [1 ]
机构：
[1] Austin res Inst, Canc Immunotherapy Lab, Burnet Inst, Heidelberg, Vic 3081, Australia
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2007年 / 22卷 / 08期
关键词：
mucin; MUC1; breast cancer; immunotherapy; signaling transduction;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MUC1 is a potential target in breast cancer immunotherapy as MUC1 is overexpressed in breast cancer, and is absent or expressed in low level in normal mammary gland. In addition, MUC1 is mostly aberrantly underglycosylated in cancer and the antigens on the cancer surface are different from normal cell. Therefore targeting MUC1 for cancer immunotherapy can exploit the difference between cancer and normal cells, and eliminating the cancerous cells while leaving the normal mammary cells unharmed. This review will focus on the recent advance of MUC1 breast cancer immunotherapy currently being investigated.
引用
收藏
页码：905 / 922
页数：18
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