MUC1 immunotherapy

被引：94
|
作者：
Beatson, Richard E. [1 ]
Taylor-Papadimitriou, Joyce [1 ]
Burchell, Joy M. [1 ]
机构：
[1] Kings Coll London, Guys Hosp, Breast Canc Biol Grp, London SE1 9RT, England
来源：
IMMUNOTHERAPY | 2010年 / 2卷 / 03期
关键词：
aberrant O-linked glycosylation; cancer; episialin; immunotherapy; MUC1; polymorphic epithelial mucin; BREAST-CANCER PATIENTS; HUMORAL IMMUNE-RESPONSE; CYTOTOXIC T-LYMPHOCYTES; TUMOR-ASSOCIATED MUC1; SQUAMOUS-CELL CARCINOMA; O-LINKED GLYCOSYLATION; PULSED DENDRITIC CELLS; GROWTH-FACTOR RECEPTOR; PHASE-I TRIAL; C-TYPE LECTIN;
D O I：
10.2217/IMT.10.17
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies. This review highlights the main avenues of research in this field, focusing on adenocarcinomas, from the preclinical to clinical; the problems and possible solutions associated with each approach; and speculates on the direction of MUC1 immunotherapeutic research over the next 5-10 years.
引用
收藏
页码：305 / 327
页数：23
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