MUC1 and breast cancer

被引：0
|
作者：
Apostolopoulos, V [1 ]
Pietersz, GA [1 ]
McKenzie, IFC [1 ]
机构：
[1] Austin & Repatriat Med Ctr, Austin Res Inst, Heidelberg, Vic 3084, Australia
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 1999年 / 1卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The development of an effective immunotherapeutic approach to cancer is now a major focus of research, and despite impressive progress over the last 10 years there are still many hurdles to overcome to elicit an effective immune response which will totally eradicate the cancer. Mucins (MUC1) have attracted interest as potential targets for immunotherapy of cancers of breast, pancreas, ovary and others, and we have demonstrated that mannan, a polymannose carbohydrate is an effective carrier for MUC1 in eliciting a cellular immune response. Several clinical trials are in progress to evaluate the immunogenicity of MUC1 and its suitability as to use for immunotherapy/vaccine for breast cancer.
引用
收藏
页码：98 / 103
页数：6
相关论文
共 50 条
  • [1] Immunity to MUC1 in pancreatic and breast cancer
    Geller, B. A.
    Lepisto, A. J.
    Ahrendt, G. M.
    Finn, O. J.
    Ramanathan, R. K.
    Brufsky, A. M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [2] New immunoassays for MUC1 in breast cancer
    Norum, LF
    Sauren, AM
    Rye, PD
    Nustad, K
    [J]. TUMOR BIOLOGY, 2001, 22 (04) : 216 - 222
  • [3] MUC1 and cancer
    Taylor-Papadimitriou, J
    Burchell, J
    Miles, DW
    Dalziel, M
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1455 (2-3): : 301 - 313
  • [4] Advances of MUC1 as a target for breast cancer immunotherapy
    Yang, E.
    Hu, X. F.
    Xing, P. X.
    [J]. HISTOLOGY AND HISTOPATHOLOGY, 2007, 22 (08) : 905 - 922
  • [5] Expression of MUC1, MUC2 and oligosaccharide epitopes in breast cancer: Prognostic significance of a sialylated MUC1 epitope
    Baldus, SE
    Wienand, JR
    Werner, JP
    Landsberg, S
    Drebber, U
    Hanisch, FG
    Dienes, HP
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2005, 27 (05) : 1289 - 1297
  • [6] Functional studies of the MUC1 oncoprotein in human breast cancer
    Hattrup, Christine L.
    Gendler, Sandra J.
    [J]. CANCER RESEARCH, 2006, 66 (08)
  • [7] Analysis of the promoter of the MUC1 gene overexpressed in breast cancer
    Zaretsky, JZ
    Sarid, R
    Aylon, Y
    Mittelman, LA
    Wreschner, DH
    Keydar, I
    [J]. FEBS LETTERS, 1999, 461 (03) : 189 - 195
  • [8] IS EPISIALIN MUC1 INVOLVED IN BREAST-CANCER PROGRESSION
    HILKENS, J
    VOS, HL
    WESSELING, J
    BOER, M
    STORM, J
    VANDERVALK, S
    CALAFAT, J
    PATRIARCA, C
    [J]. CANCER LETTERS, 1995, 90 (01) : 27 - 33
  • [9] MUC1: A metabolic regulator in triple negative breast cancer
    Goode, Gennifer D.
    Chaika, Nina
    Purohit, Vinee
    Gunda, Venugopal
    Singh, Pankaj
    [J]. CANCER RESEARCH, 2016, 76
  • [10] Inhibiting breast cancer progression with a MUC1 mimetic peptide
    Bitler, Benjamin G.
    Menzl, Ina
    Huerta, Carmen
    Schroeder, Joyce A.
    [J]. CLINICAL & EXPERIMENTAL METASTASIS, 2009, 26 (07) : 874 - 874
12345