MUC1 and breast cancer

被引：0
|
作者：
Apostolopoulos, V [1 ]
Pietersz, GA [1 ]
McKenzie, IFC [1 ]
机构：
[1] Austin & Repatriat Med Ctr, Austin Res Inst, Heidelberg, Vic 3084, Australia
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 1999年 / 1卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The development of an effective immunotherapeutic approach to cancer is now a major focus of research, and despite impressive progress over the last 10 years there are still many hurdles to overcome to elicit an effective immune response which will totally eradicate the cancer. Mucins (MUC1) have attracted interest as potential targets for immunotherapy of cancers of breast, pancreas, ovary and others, and we have demonstrated that mannan, a polymannose carbohydrate is an effective carrier for MUC1 in eliciting a cellular immune response. Several clinical trials are in progress to evaluate the immunogenicity of MUC1 and its suitability as to use for immunotherapy/vaccine for breast cancer.
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页码：98 / 103
页数：6
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