Effect of gum arabic-modified alginate on physicochemical properties, release kinetics, and storage stability of liquid-core hydrogel beads

被引：50
|
作者：
Tsai, Fu-Hsuan [1 ]
Kitamura, Yutaka [2 ]
Kokawa, Mito [2 ]
机构：
[1] Univ Tsukuba, Grad Sch Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan
[2] Univ Tsukuba, Fac Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan
来源：
CARBOHYDRATE POLYMERS | 2017年 / 174卷
关键词：
Radish by-product; Micro wet milling; Gum arabic; Encapsulation; Reverse spherification; In vitro release; ANTIOXIDANT ACTIVITY; DELIVERY-SYSTEMS; DRUG-RELEASE; CALCIUM; CHITOSAN; MICROENCAPSULATION; GELATION; NANOPARTICLES; CARRIER; WEIGHT;
D O I：
10.1016/j.carbpol.2017.07.031
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Different weight ratios of alginate/gum arabic (GA) solutions were prepared to serve as the wall material of liquid-core hydrogel beads (LHB) that were formulated to protect the total phenolic compounds (TP) of radish by-product juice from degradation during storage and release in simulated gastrointestinal fluid. The diameter of LHB ranged from 4.63 to 5.66 mm with a sphericity lower than 0.05. LHB formulated with 25% GA (AGB0.25) exhibited the highest hardness (26.63 N), and those formulated with 50% GA (AGB0.50) exhibited the highest loading efficiency (86.67%). AGB0.25 was effective in preventing TP from degrading during storage with a decay rate (k) of 6.10 x 10(-3) day(-1) and a half-life (t(1/2)) of 113.63 days, it showed the slowest release of TP in simulated gastric fluid (k = 2.25 x 10(-6)), and the release mechanism followed Fickian diffusion. The results suggest that GA is effective in improving the physicochemical properties of alginate. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1069 / 1077
页数：9
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