Preparation of Gum Arabic-Maltose-Pea Protein Isolate Complexes for 1-Octacosanol Microcapsule: Improved Storage Stability, Sustained Release in the Gastrointestinal Tract, and Its Effect on the Lipid Metabolism of High-Fat-Diet-Induced Obesity Mice

被引：4

作者：

Ding, Yin-Yi ^{[1
,2
]}

Pan, Yuxiang ^{[1
]}

Zhang, Wanyue ^{[1
]}

Sheng, Yijing ^{[3
]}

Cao, Yanyun ^{[1
,2
]}

Gu, Zhenyu ^{[1
]}

Shen, Qing ^{[1
,4
]}

Wang, Qingcheng ^{[5
]}

Chen, Xi ^{[6
]}

机构：

[1] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Hangzhou 310018, Peoples R China

[2] Zhejiang Gongshang Univ, Food Nutr Sci Ctr, Hangzhou 310018, Peoples R China

[3] Nanchang Univ, Coll Food Sci & Technol, Nanchang 330031, Peoples R China

[4] Zhejiang Gongshang Univ, Inst Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Zhejiang Prov Joint Key Lab Aquat Prod Proc, Hangzhou 310018, Peoples R China

[5] Hangzhou Linping Hosp Tradit Chinese Med, Hangzhou 311106, Peoples R China

[6] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou 310000, Peoples R China

来源：

FOODS | 2023年 / 12卷 / 01期

关键词：

1-Octacosanol; microcapsule; storage stability; sustained release; HFD-induced obesity mice; SOY PROTEIN; IN-VITRO; DIGESTION; NANOPARTICLES; ENCAPSULATION; OCTACOSANOL; SOLUBILITY; EMULSIONS; DELIVERY; ACID;

D O I：

10.3390/foods12010112

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

1-Octacosanol (Octa) is a natural compound with several beneficial properties. However, its poor water solubility and metabolism in the digestive tract reduce its efficacy. The Octa-GA-Malt-PPI microcapsule was prepared as follows: gum Arabic (GA):maltose (Malt):pea protein isolate (PPI) = 2:1:2; core:shell = 1:7.5; emulsification temperature 70 degrees C; pH 9.0. An in vitro simulated gastrointestinal tract was used to analyze the digestion behavior. C57BL/6 mice were selected to establish an obesity model induced by a high-fat diet (HFD) to evaluate the effect of Octa monomer and the microcapsule. The diffusivity in water and storage stability of Octa improved after encapsulation. The microcapsule was ascribed to electrostatic interactions, hydrogen bonding, and hydrophobic interactions. The sustained release of Octa from the microcapsule was observed in a simulated gastrointestinal tract. Compared with Octa monomer, the microcapsule was more effective in alleviating the symptoms of weight gain, hypertension, and hyperlipidemia induced by HFD in mice. In conclusion, the construction of microcapsule structure can improve the dispersibility and stability of Octa in water, achieve sustained release of Octa in the gastrointestinal tract, and improve its efficiency in alleviating the effects of HFD on the body.

引用

页数：18