Lymphangiogenesis: Molecular Mechanisms and Future Promise

被引：1083
|
作者：
Tammela, Tuomas [1 ,2 ]
Alitalo, Kari [1 ,2 ]
机构：
[1] Univ Helsinki, Lab Mol Canc Biol, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Haartman Inst, Biomedicum Helsinki, FIN-00014 Helsinki, Finland
来源：
CELL | 2010年 / 140卷 / 04期
关键词：
GROWTH-FACTOR-C; LYMPH-NODE LYMPHANGIOGENESIS; ENDOTHELIAL PROGENITOR CELLS; VEGF-C; BREAST-CANCER; TUMOR-METASTASIS; INFLAMMATORY LYMPHANGIOGENESIS; EMBRYONIC LYMPHANGIOGENESIS; PLATELET ACTIVATION; VESSEL DEVELOPMENT;
D O I：
10.1016/j.cell.2010.01.045
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases. © 2010 Elsevier Inc. All rights reserved.
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页码：460 / 476
页数：17
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