Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population

被引：9
|
作者：
Khawaja, Muhammad Rizwanulhaq
Taj, Fawad
Ahmad, Usman
Saleheen, Danish
Jafar, Tazeen
Frossard, Philippe M.
机构：
[1] Aga Khan Univ, Coll Med, Fac Hlth Sci, Dept Biol & Biomed Sci, Karachi 74800, Pakistan
[2] Aga Khan Univ, Fac Hlth Sci, Coll Med, Dept Med, Karachi, Pakistan
[3] Aga Khan Univ, Fac Hlth Sci, Coll Med, Dept Community Hlth Sci, Karachi, Pakistan
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 116卷 / 01期
关键词：
hypertension; endothelium; eNOS gene; polymorphism; Pathan;
D O I：
10.1016/j.ijcard.2006.04.019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 nonnotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphisin to essential hypertension. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：113 / 115
页数：3
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