Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population

被引：9
|
作者：
Khawaja, Muhammad Rizwanulhaq
Taj, Fawad
Ahmad, Usman
Saleheen, Danish
Jafar, Tazeen
Frossard, Philippe M.
机构：
[1] Aga Khan Univ, Coll Med, Fac Hlth Sci, Dept Biol & Biomed Sci, Karachi 74800, Pakistan
[2] Aga Khan Univ, Fac Hlth Sci, Coll Med, Dept Med, Karachi, Pakistan
[3] Aga Khan Univ, Fac Hlth Sci, Coll Med, Dept Community Hlth Sci, Karachi, Pakistan
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 116卷 / 01期
关键词：
hypertension; endothelium; eNOS gene; polymorphism; Pathan;
D O I：
10.1016/j.ijcard.2006.04.019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 nonnotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphisin to essential hypertension. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：113 / 115
页数：3
相关论文
共 50 条
  • [21] Endothelial Nitric Oxide Synthase (G894T) Gene Polymorphism in a Random Sample of the Egyptian Population: Comparison with Myocardial Infarction Patients
    Gad, Mohamed Z.
    Rahman, Mohamed F. Abdel
    Hashad, Ingy M.
    Abdel-Maksoud, Sahar M.
    Farag, Nabil M.
    Abou-Aisha, Khaled
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2012, 16 (07) : 695 - 700
  • [22] Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls
    Jaramillo, Priscilla C.
    Munoz, Alvaro M.
    Lanas, Cecilia M.
    Lanas, Femando Z.
    Salazar, Luis A.
    CLINICA CHIMICA ACTA, 2006, 371 (1-2) : 102 - 106
  • [23] Heart failure and endothelial nitric oxide synthase G894T gene polymorphism frequency variations within ancestries
    Oliveira, Romulo V. M.
    Albuquerque, Felipe N.
    Duque, Gustavo S.
    Freitas, Rossana G. A.
    Carvalho, Elizeu F.
    Brandao, Andrea A.
    Silva, Dayse A.
    Mourilhe-Rocha, Ricardo
    Albuquerque, Denilson C.
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2018, 73 : 60 - 65
  • [24] The Relationship between Endothelial Nitric Oxide Synthase Gene Polymorphism (G894T) and Isole Coronary Artery Ectasia
    Icli, Atilla
    Altinbas, Ahmet
    Turker, Yasin
    Yucel, Habil
    Akcay, Salaheddin
    Sutcu, Recep
    Aksoy, Fatih
    Arslan, Akif
    Tayyar, Senol
    Uysal, Bayram Ali
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (18) : C207 - C207
  • [25] Endothelial Nitric Oxide Synthase Gene [G894T] polymorphism as a possible risk factor in aneurysmal subarachnoid haemorrhage
    Ü. Özüm
    N. Bolat
    E. Gül
    Ö. Özdemir
    Acta Neurochirurgica, 2008, 150 : 57 - 62
  • [26] Endothelial nitric oxide synthase gene polymorphism (G894T) and levels of inflammation and oxidation markers; The ATTICA study
    Chrysohoou, C
    Pitsavos, C
    Panagiotakos, D
    Antoniades, C
    Skoumas, J
    Tousoulis, D
    Toutouzas, P
    Stefanadis, C
    EUROPEAN HEART JOURNAL, 2003, 24 : 348 - 348
  • [27] Endothelial Nitric Oxide Synthase Gene [G894T] polymorphism as a possible risk factor in aneurysmal subarachnoid haemorrhage
    Oezuem, Ue.
    Bolat, N.
    Guel, E.
    Oezdemir, Oe.
    ACTA NEUROCHIRURGICA, 2008, 150 (01) : 57 - 61
  • [28] Endothelial nitric oxide synthase polymorphism (G894T) and nonarteritic anterior ischemic optic neuropathy
    Giannopoulos, Sotirios
    Markoula, Sofia
    Asproudis, Ioannis
    Galidi, Anna
    Nikas, Alexios
    Kyritsis, Athanassios P.
    Georgiou, Ioannis
    VISUAL NEUROSCIENCE, 2010, 27 (5-6) : 183 - 185
  • [29] Endothelial nitric oxide synthase G894T polymorphism increases the risk of infertility in women with endometriosis
    Silva, R. C. P. C. E.
    de Faria, L. C.
    Silva, K. S. F. E.
    Moura, K. K. V. O.
    Ribeiro Junior, C. L.
    Guillo, L. A.
    GENETICS AND MOLECULAR RESEARCH, 2019, 18 (02)
  • [30] An association between the endothelial nitric oxide synthase gene G894T polymorphism and premature coronary artery disease: a meta-analysis
    Zhu, Boqian
    Si, Xinmin
    Gong, Yaoyao
    Yan, Gaoliang
    Wang, Dong
    Qiao, Yong
    Liu, Bo
    Hou, Jiantong
    Tang, Chengchun
    ONCOTARGET, 2017, 8 (44) : 77990 - 77998
12345