Hepatocyte nuclear factor-4α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

被引：58

作者：

Boustead, JN ^{[1
]}

Stadelmaier, BT ^{[1
]}

Eeds, AM ^{[1
]}

Wiebe, PO ^{[1
]}

Svitek, CA ^{[1
]}

Oeser, JK ^{[1
]}

O'Brien, RM ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Physiol & Mol Biophys, Sch Med, Nashville, TN 37232 USA

来源：

BIOCHEMICAL JOURNAL | 2003年 / 369卷 / 01期

关键词：

diabetes; gluconeogenesis; HNF-4; phosphoenolpyruvate carboxykinase;

D O I：

10.1042/BJ20021382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4alpha.

引用

页码：17 / 22

页数：6

共 12 条

[11] Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-γ coactivator 1α in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c
Ponugoti, Bhaskar
Fang, Sungsoon
Kemper, Jongsook Kim
MOLECULAR ENDOCRINOLOGY, 2007, 21 (11) : 2698 - 2712
[12] Hepatocyte nuclear factor-4α regulates the human apolipoprotein AV gene:: Identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-γ coactivator-1α , AMP-activated protein kinase, and mitogen-activated protein kinase pathway
Prieur, X
Schaap, FG
Coste, H
Rodríguez, JC
MOLECULAR ENDOCRINOLOGY, 2005, 19 (12) : 3107 - 3125

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