Hepatocyte nuclear factor-4α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

被引：58
|
作者：
Boustead, JN [1 ]
Stadelmaier, BT [1 ]
Eeds, AM [1 ]
Wiebe, PO [1 ]
Svitek, CA [1 ]
Oeser, JK [1 ]
O'Brien, RM [1 ]
机构：
[1] Vanderbilt Univ, Dept Physiol & Mol Biophys, Sch Med, Nashville, TN 37232 USA
来源：
BIOCHEMICAL JOURNAL | 2003年 / 369卷 / 01期
关键词：
diabetes; gluconeogenesis; HNF-4; phosphoenolpyruvate carboxykinase;
D O I：
10.1042/BJ20021382
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4alpha.
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收藏
页码：17 / 22
页数：6
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