Parathyroid hormone oxidation in chronic kidney disease: clinical relevance?

被引：2

作者：

Drueeke, Tilman B. ^{[1
,2
]}

Floege, Juergen ^{[3
]}

机构：

[1] Paris Sud Univ, Inserm U 1018, Ctr Rech Epidemiol & Sante Populat CESP, Paris lle de France Ouest Univ, Villejuif, France

[2] Paris Saclay Univ, Villejuif, France

[3] Rheinisch Westfalische Tech Hsch Aachen, Univ Hosp, Dept Nephrol & Clin Immunol, Aachen, Germany

来源：

KIDNEY INTERNATIONAL | 2021年 / 99卷 / 05期

关键词：

PTH;

D O I：

10.1016/j.kint.2021.01.019

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In chronic kidney disease, parathyroid hormone (PTH), like all proteins, can undergo post-translational modifications, including oxidation. This can lead to structural and functional changes of the hormone. It has been hypothesized that currently used PTH measurement methods do not adequately reflect PTH-related bone and cardiovascular abnormalities in chronic kidney disease owing to the presence of oxidized, biologically inactive PTH in the circulation. Ursem et al. now report a strong correlation between serum non-oxidized and total PTH, and comparable associations with histomorphometric and circulating bone turnover markers, pleading against this hypothesis.

引用

页码：1070 / 1072

页数：3

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