Parathyroid hormone oxidation in chronic kidney disease: clinical relevance?

被引：2
|
作者：
Drueeke, Tilman B. [1 ,2 ]
Floege, Juergen [3 ]
机构：
[1] Paris Sud Univ, Inserm U 1018, Ctr Rech Epidemiol & Sante Populat CESP, Paris lle de France Ouest Univ, Villejuif, France
[2] Paris Saclay Univ, Villejuif, France
[3] Rheinisch Westfalische Tech Hsch Aachen, Univ Hosp, Dept Nephrol & Clin Immunol, Aachen, Germany
来源：
KIDNEY INTERNATIONAL | 2021年 / 99卷 / 05期
关键词：
PTH;
D O I：
10.1016/j.kint.2021.01.019
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In chronic kidney disease, parathyroid hormone (PTH), like all proteins, can undergo post-translational modifications, including oxidation. This can lead to structural and functional changes of the hormone. It has been hypothesized that currently used PTH measurement methods do not adequately reflect PTH-related bone and cardiovascular abnormalities in chronic kidney disease owing to the presence of oxidized, biologically inactive PTH in the circulation. Ursem et al. now report a strong correlation between serum non-oxidized and total PTH, and comparable associations with histomorphometric and circulating bone turnover markers, pleading against this hypothesis.
引用
收藏
页码：1070 / 1072
页数：3
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