Synthesis and Class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines

被引：5
|
作者：
Kanojia, RM [1 ]
Salata, JJ [1 ]
Kauffman, J [1 ]
机构：
[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 24期
关键词：
D O I：
10.1016/S0960-894X(00)00581-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC50 of 3 nM, ranks as one of the most potent (in vitro) compounds reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2819 / 2823
页数：5
相关论文
共 50 条
  • [21] Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones
    V. L. Gein
    E. V. Pastukhova
    Russian Journal of General Chemistry, 2021, 91 : 1261 - 1264
  • [22] Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones
    V. L. Gein
    E. A. Buldakova
    A. N. Korol
    G. A. Veikhman
    M. V. Dmitriev
    Russian Journal of General Chemistry, 2018, 88 : 908 - 911
  • [23] Synthesis of 1-Aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones
    V. L. Gein
    E. V. Pastukhova
    Russian Journal of General Chemistry, 2021, 91 : 40 - 43
  • [24] Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones
    Gein, V. L.
    Pastukhova, E., V
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2021, 91 (07) : 1261 - 1264
  • [25] Synthesis of 1-Aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones
    Gein, V. L.
    Pastukhova, E. V.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2021, 91 (01) : 40 - 43
  • [26] Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones
    Gein, V. L.
    Buldakova, E. A.
    Korol, A. N.
    Veikhman, G. A.
    Dmitriev, M. V.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (05) : 908 - 911
  • [27] SYNTHESIS OF NOVEL (ARYLOXY)PROPANOLAMINES AND RELATED-COMPOUNDS POSSESSING BOTH CLASS-II AND CLASS-III ANTIARRHYTHMIC ACTIVITY
    LIS, R
    MORGAN, TK
    MARISCA, AJ
    GOMEZ, RP
    LIND, JM
    DAVEY, DD
    PHILLIPS, GB
    SULLIVAN, ME
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (10) : 2883 - 2891
  • [28] SYNTHESIS AND ANTITUBERCULOSIS ACTIVITY OF O-AROYL-β-(4-PHENYLPIPERAZIN-1-YL)PROPIOAMIDOXIMES
    Kayukova, L. A.
    Orazbaeva, M. A.
    Bismilda, V. L.
    Chingisova, L. T.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2010, 44 (07) : 356 - 359
  • [29] Synthesis and antituberculosis activity of O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes
    L. A. Kayukova
    M. A. Orazbaeva
    V. L. Bismilda
    L. T. Chingisova
    Pharmaceutical Chemistry Journal, 2010, 44 : 356 - 359
  • [30] SYNTHESIS, CARDIAC ELECTROPHYSIOLOGY, AND BETA-BLOCKING ACTIVITY OF NOVEL ARYLPIPERAZINES WITH POTENTIAL AS CLASS II/III ANTIARRHYTHMIC AGENTS
    PHILLIPS, GB
    MORGAN, TK
    LUMMA, WC
    GOMEZ, RP
    LIND, JM
    LIS, R
    ARGENTIERI, T
    SULLIVAN, ME
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (04) : 743 - 750
12345