An extremely active catalyst for the Negishi cross-coupling reaction

被引：375

作者：

Milne, JE ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 40期

关键词：

D O I：

10.1021/ja0474493

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri-and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.

引用

页码：13028 / 13032

页数：5

共 50 条

[1] Negishi Cross-Coupling Reaction as a Route to Isocombretastatins
Malysheva, Yulia B.
Buchvalova, Svetlana Y.
Svirshchevskaya, Elena V.
Fokin, Valery V.
Fedorov, Alexey Y.
[J]. SYNLETT, 2013, 24 (14) : 1772 - 1776
[2] POxAP Precatalysts and the Negishi Cross-Coupling Reaction
Tang, Shuang-Qi
Schmitt, Martine
Bihel, Frederic J. J.
[J]. SYNTHESIS-STUTTGART, 2020, 52 (01): : 51 - 59
[3] New insights into the mechanism of the Negishi cross-coupling reaction
Organ, Michael G.
Hunter, Howard N.
Bohme, Diethart K.
Hadei, Niloufar
Blagojevic, Voislav
Achonduh, George T.
Avola, Stephanie
McCann, Lucas
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[4] A Negishi cross-coupling reaction enables the total synthesis of (+)-stachyflin
Haut, Franz-Lucas
Speck, Klaus
Wildermuth, Raphael
Moeller, Kristof
Mayer, Peter
Magauer, Thomas
[J]. TETRAHEDRON, 2018, 74 (26) : 3348 - 3357
[5] Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence
Sathiyalingam, Shainthavaan
Roesner, Stefan
[J]. ADVANCED SYNTHESIS & CATALYSIS, 2022, 364 (10) : 1769 - 1774
[6] Synthetic Aromatic Amino Acids from a Negishi Cross-Coupling Reaction
Suhartono, Marcel
Schneider, Angelika E.
Duerner, Gerd
Goebel, Michael W.
[J]. SYNTHESIS-STUTTGART, 2010, (02): : 293 - 303
[7] Online and In Situ Monitoring of the Exchange, Transmetalation, and Cross-Coupling of a Negishi Reaction
Malig, Thomas C.
Kumar, Archana
Kurita, Kenji L.
[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2022, 26 (05) : 1514 - 1519
[8] New insights into the Negishi cross-coupling reaction: The role of salt additives
Hoi, Ka Hou
Calimsiz, Selcuk
McCann, Lucas
Organ, Michael
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
[9] Recent Developments in Negishi Cross-Coupling Reactions
Haas, Diana
Hammann, Jeffrey M.
Greiner, Robert
Knochel, Paul
[J]. ACS CATALYSIS, 2016, 6 (03): : 1540 - 1552
[10] Highly active PdCu/graphene catalyst for an efficient Suzuki cross-coupling reaction
M., Xiaojing
Gao, Lingfeng
Weng, Zhentao
Yang, Hua
Sun, Xu
[J]. NEW JOURNAL OF CHEMISTRY, 2020, 44 (47) : 20525 - 20529

← 1 2 3 4 5 →