An extremely active catalyst for the Negishi cross-coupling reaction

被引：375
|
作者：
Milne, JE [1 ]
Buchwald, SL [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 40期
关键词：
D O I：
10.1021/ja0474493
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri-and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.
引用
收藏
页码：13028 / 13032
页数：5
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