Synthetic Aromatic Amino Acids from a Negishi Cross-Coupling Reaction

被引：12

作者：

Suhartono, Marcel ^{[1
]}

Schneider, Angelika E. ^{[1
]}

Duerner, Gerd ^{[1
]}

Goebel, Michael W. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany

来源：

SYNTHESIS-STUTTGART | 2010年 / 02期

关键词：

amino alcohols; chiral pool; nickel catalyst; RNA ligand; zinc organyls; ALPHA-AMINO; ORGANOZINC REAGENTS; ASYMMETRIC-SYNTHESIS; TAR RNA; DERIVATIVES; HOMOPHENYLALANINE; REPLICATION; INHIBITORS; CHEMISTRY; BROMIDES;

D O I：

10.1055/s-0029-1217124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An N,O-protected, iodinated bishomoalanine derivative, safely available from glutamic acid, reacts with aryl halides in a Negishi reaction in high yields. From the coupling product, Fmoc-protected amino acids with aromatic and heteroaromatic side chains were generated in high yields by racemization-free procedures. These monomers could be used for solid-phase peptide synthesis.

引用

页码：293 / 303

页数：11

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