Association between HLA-DR4 haplotypes and tuberculin skin test response in the Ache population

被引：6
|
作者：
Lindenau, J. D. [1 ]
Guimaraes, L. S. P. [2 ]
Hurtado, A. M. [3 ]
Hill, K. R. [3 ]
Tsuneto, L. T. [4 ]
Salzano, F. M. [1 ]
Petzl-Erler, M. L. [5 ]
Hutz, M. H. [1 ]
机构：
[1] Univ Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, BR-91501970 Porto Alegre, RS, Brazil
[2] Hosp Clin Porto Alegre, Unidade Epidemiol & Estat, Porto Alegre, RS, Brazil
[3] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ USA
[4] Univ Estadual Maringa, Dept Anal Clin, Maringa, PR, Brazil
[5] Univ Fed Parana, Dept Genet, BR-80060000 Curitiba, PR, Brazil
来源：
TISSUE ANTIGENS | 2014年 / 84卷 / 05期
关键词：
Amerindians; anergy; human leukocyte antigen; tuberculin skin test response response; tuberculosis; HUMAN-LEUKOCYTE ANTIGEN; PULMONARY TUBERCULOSIS; HLA-DR; BALANCING SELECTION; IRANIAN PATIENTS; ALLELES; DQ; SUSCEPTIBILITY; INDIANS; GENES;
D O I：
10.1111/tan.12451
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Ache population. Poisson Regression was employed to assess risk genotypes. DRB1*04, DQA1*03 and DQB1*03:02 were associated with TST response in this population.
引用
收藏
页码：479 / 483
页数：5
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