C-cinnamoyl glycosides as a new class of anti-filarial agents

被引：13

作者：

Roy, Priya ^{[3
]}

Dhara, Debashis ^{[1
]}

Parida, Pravat Kumar ^{[1
]}

Kar, Rajiv Kumar ^{[2
]}

Bhunia, Anirban ^{[2
]}

Jana, Kuladip ^{[1
]}

Babu, Santi P. Sinha ^{[3
]}

Misra, Anup Kumar ^{[1
]}

机构：

[1] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7-M, Kolkata 700054, India

[2] Bose Inst, Dept Biophys, P-1-12,CIT Scheme 7-M, Kolkata 700054, India

[3] Visva Bharati Univ, Parasitol Lab, Dept Zool, Ctr Adv Studies, Santini Ketan 731235, W Bengal, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 114卷

关键词：

C-glycosides; Anti-filarial; Wuchereria bancrofti; Setaria cervi; Aldol reaction; MTT reduction assay; QSAR; ANTIFILARIAL ACTIVITY; LYMPHATIC FILARIASIS; SELECTIVE INHIBITORS; APOPTOSIS; PARASITE; KETONES; IDENTIFICATION; MICROFILARIAE; DISEASE; PHASE;

D O I：

10.1016/j.ejmech.2016.03.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of C-cinnamoyl glycosides has been synthesized in good yield by the BF3 center dot OEt2 catalyzed aldol condensation of C-glycosylated acetone derivative with a variety of aromatic aldehydes. The synthesized compounds were evaluated for their potential as anti-filarial agents against bovine filarial parasite Setaria cervi and human filariid Wuchereria bancrofti using a number of biological assays such as relative movability (RM) assessment and MTT reduction assay. Among twenty seven test compounds six compounds were found active in terms of MIC, IC50 and LC50 values. Further biological studies were carried out using three lead compounds because of their significantly low MIC values and IC50 values compared to the standard anti-filarial drug Ivermectin. In addition, structure activity relationship study of the test compounds has been carried out using 3D-QSAR analysis. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：308 / 317

页数：10

共 50 条

[21] KETO C-GLYCOSIDES - A NEW CLASS OF ANTITUMOR COMPOUNDS
HERSCOVICI, J
BENNANIBAITI, MI
FRAYSSINET, C
ANTONAKIS, K
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (08) : 395 - 398
[22] Bromoketone C-glycosides, a new class of β-glucanase inactivators
J Am Chem Soc, 40 (10326-10331):
[23] Molecular docking-based virtual screening, molecular dynamic simulation, and 3-D QSAR modeling of some pyrazolopyrimidine analogs as potent anti-filarial agents
Fabian Audu Ugbe
Gideon Adamu Shallangwa
Adamu Uzairu
Ibrahim Abdulkadir
In Silico Pharmacology, 10 (1)
[24] PYRANOCOUMARINS: A NEW CLASS OF ANTI-HYPERGLYCEMIC AND ANTI-DYSLIPIDEMIC AGENTS
Kumar, Promod
Ahmad, Pervez
Bhatia, Gitika
Srivastava, Arvind K.
Kumar, Atul
MEDICINAL CHEMISTRY RESEARCH, 2010, 19 : S103 - S103
[25] Pyranocoumarins: A new class of anti-hyperglycemic and anti-dyslipidemic agents
Kumar, Atul
Maurya, Ram Awatar
Sharma, Siddharth
Ahmad, Pervez
Singh, A. B.
Bhatia, Gitika
Srivastava, Arvind K.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (22) : 6447 - 6451
[26] The palmitoylethanolamide family: A new class of anti-inflammatory agents?
Lambert, DM
Vandevoorde, S
Jonsson, KO
Fowler, CJ
CURRENT MEDICINAL CHEMISTRY, 2002, 9 (06) : 663 - 674
[27] Statins in hypertension. Are they a new class of anti hypertensive agents?
Feldstein, Carlos A.
REVISTA LATINOAMERICANA DE HIPERTENSION, 2008, 3 (02): : 33 - 38
[28] TAT INHIBITORS - A NEW CLASS OF ANTI-HIV AGENTS
TAM, S
BORGESE, I
CISLO, A
EARLEY, J
HOLMAN, M
HSU, MC
HURYN, DM
KEITH, DD
LUK, KC
RICHOU, A
SCHUTT, A
SLUBOSKI, B
RICHMAN, D
VOLSKY, D
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 372 - ORGN
[29] Protein splicing inhibitors as a new class of anti mycobacterial agents
Paulus, Henry
DRUGS OF THE FUTURE, 2007, 32 (11) : 973 - 984
[30] New class of Rhodamine-based beta-C-Glycosides and Their Applications
Rajasekar, Mani
Das, Thangamuthu Mohan
TRENDS IN CARBOHYDRATE RESEARCH, 2016, 8 (01) : 26 - 35

← 1 2 3 4 5 →