KETO C-GLYCOSIDES - A NEW CLASS OF ANTITUMOR COMPOUNDS

被引：7

作者：

HERSCOVICI, J ^{[1
]}

BENNANIBAITI, MI ^{[1
]}

FRAYSSINET, C ^{[1
]}

ANTONAKIS, K ^{[1
]}

机构：

[1] CNRS,INST RECH SCI CANC,PATHOL CELLULAIRE LAB,F-94801 VILLEJUIF,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80263-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-keto unsaturated C-glycosides was synthesized from 0-acetyl C-glycosides. These compounds and some parent 2-keto unsaturated C-glycosides were tested for cytotoxic activity against LFCl2A cells (Rat hepatocarcinoma cells). C-Glycosides with an acyclic aglycone have not been found cyctotoxic, whereas 1-methyl cyclohexenyl and methylene cyclohexenyl C-glycosides possessed IC50 values of 9-0.03-mu-M with 11 being the most potent.

引用

页码：395 / 398

页数：4

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