Mapping of new recessive cataract gene (lr2) in the mouse

被引：9
|
作者：
Song, CW
Okumoto, M
Mori, N
Kim, JS
Han, SS
Esaki, K
机构：
[1] UNIV OSAKA PREFECTURE, ADV SCI & TECHNOL RES INST, DEPT APPL BIOSCI, DIV BION, SAKAI, OSAKA 593, JAPAN
[2] KONKUK UNIV, DEPT VET MED, KWANGIJN KU, SEOUL 133701, SOUTH KOREA
[3] KONKUK UNIV, ANIM RESOURCES RES CTR, KWANGJIN KU, SEOUL 133701, SOUTH KOREA
[4] KOREA RES INST CHEM TECHNOL, TOXICOL RES CTR, TAEJON 305606, SOUTH KOREA
来源：
MAMMALIAN GENOME | 1997年 / 8卷 / 12期
关键词：
D O I：
10.1007/s003359900613
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new strain of mice with cataracts was developed in BALB/cHeA and STS/A recombinant inbred strain, CXS4 (D). In this study the mapping of spontaneous autosomal recessive cataract mutation is described. This mutation was characterized by ruptures of the lens nucleus, vitreous chamber through the posterior capsule, and the vacuolization of the lens. For the linkage analysis, we produced two kinds of backcross progenies, (BALB/cHeA x D)F-1 and (STS/A x D)F-1 females crossed to D male mice. The gene (lr2, lens rupture2) was mapped to the central part of Chromosome(Chr) 14, 0.7 +/- 0.7cM from the micosatellite marker D14Mit28.
引用
收藏
页码：927 / 931
页数：5
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