Studies on 6-[(dimethylamino)methylenelaminouracil:: a facile one-pot synthesis of novel pyrimido[4,5-d]pyrimidine derivatives

被引：57
|
作者：
Prajapati, D [1 ]
Thakur, AJ
机构：
[1] Reg Res Lab, Dept Med Chem, Jorhat 785006, Assam, India
[2] Cent Univ, Dept Chem Sci, Tezpur 784028, India
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期
关键词：
amidines; pyrimido[4,5-d]pyrimidines; aryl isothiocyanates; aryl isocyanates;
D O I：
10.1016/j.tetlet.2005.01.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactions of 6-[(dimethylamino)methylene]aminouracil 1, with various heterocumulenes such as aryl isocyanates and isothiocyanates give rise to novel pyrimido[4,5-d]pyrimidines in excellent yields, after elimination of dimethylamine from the (1:1) cycloadducts and tautomerisation. This procedure provides a convenient method for direct synthesis of pyrimido[4,5-d]pyrimidine derivatives under thermal conditions. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1433 / 1436
页数：4
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