Studies on 6-[(dimethylamino)methylenelaminouracil:: a facile one-pot synthesis of novel pyrimido[4,5-d]pyrimidine derivatives

被引：57
|
作者：
Prajapati, D [1 ]
Thakur, AJ
机构：
[1] Reg Res Lab, Dept Med Chem, Jorhat 785006, Assam, India
[2] Cent Univ, Dept Chem Sci, Tezpur 784028, India
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期
关键词：
amidines; pyrimido[4,5-d]pyrimidines; aryl isothiocyanates; aryl isocyanates;
D O I：
10.1016/j.tetlet.2005.01.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactions of 6-[(dimethylamino)methylene]aminouracil 1, with various heterocumulenes such as aryl isocyanates and isothiocyanates give rise to novel pyrimido[4,5-d]pyrimidines in excellent yields, after elimination of dimethylamine from the (1:1) cycloadducts and tautomerisation. This procedure provides a convenient method for direct synthesis of pyrimido[4,5-d]pyrimidine derivatives under thermal conditions. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1433 / 1436
页数：4
相关论文
共 50 条
  • [31] Three-component, one-pot synthesis of pyrimido[4,5-b]-quinoline and pyrido[2,3-d]pyrimidine derivatives
    Hassan, N. A.
    Hegab, M. I.
    Hashem, A. I.
    Abdel-Motti, F. M.
    Hebah, S. H. A.
    Abdel-Megeid, F. M. E.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 44 (04) : 775 - 782
  • [32] Design, synthesis and evaluation of novel pyrazolo-pyrimido[4,5-d]pyrimidine derivatives as potent antibacterial and biofilm inhibitors
    Suresh, Lingala
    Kumar, P. Sagar Vijay
    Poornachandra, Y.
    Kumar, C. Ganesh
    Chandramouli, G. V. P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (06) : 1451 - 1457
  • [33] Optical, electrochemical and DFT studies of Indol-5,8-pyrimido [4,5-d]pyrimidine derivatives
    Venkatesh, Talavara
    Upendranath, Kantharaj
    Manjanna, Jayappa
    CHEMICAL DATA COLLECTIONS, 2022, 40
  • [34] Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents
    Prasoona, G.
    Kishore, B.
    Brahmeshwari, G.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2020, 59 (04): : 445 - 453
  • [35] SYNTHESES IN HETEROCYCLIC SERIES .18. SYNTHESIS OF PYRIMIDO[4,5-D]PYRIMIDINE
    BREDERECK, H
    SIMCHEN, G
    KRAMER, M
    CHEMISCHE BERICHTE-RECUEIL, 1973, 106 (11): : 3743 - 3752
  • [36] Triethyl benzyl ammonium chloride (TEBAC) catalyzed solvent-free one-pot synthesis of pyrimido[4,5-d]pyrimidines
    Akbar Mobinikhaledi
    Tahere Mosleh
    Naser Foroughifar
    Research on Chemical Intermediates, 2015, 41 : 2985 - 2990
  • [37] Triethyl benzyl ammonium chloride (TEBAC) catalyzed solvent-free one-pot synthesis of pyrimido[4,5-d]pyrimidines
    Mobinikhaledi, Akbar
    Mosleh, Tahere
    Foroughifar, Naser
    RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (05) : 2985 - 2990
  • [38] SYNTHESIS OF DERIVATIVES OF THIAZOLO 4,5-D!PYRIMIDINE .2.
    BAKER, JA
    CHATFIEL.PV
    JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1970, (18): : 2478 - &
  • [39] Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine
    Wagner, Edwin
    Al-Kadasi, Kamal
    Zimecki, Michal
    Sawka-Dobrowolska, Wanda
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (11) : 2498 - 2504
  • [40] SYNTHESIS OF DERIVATIVES OF THIAZOLO[4,5-D]PYRIMIDINE .I.
    BAKER, JA
    CHATFIELD, PV
    JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (04): : 603 - +
12345