Discovery of a new family of bicyclic dideoxy with significant antiviral activity nucleosides which inhibit HCMV by a non-nucleoside mechanism

被引：0
|
作者：
McGuigan, C
Pathirana, RN
De Clercq, E
Balzarini, J
机构：
[1] Cardiff Univ, Welsh Sch Pharm, Cardiff, S Glam, Wales
[2] Univ Leuven, Rega Inst, Louvain, Belgium
来源：
ANTIVIRAL RESEARCH | 2003年 / 57卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
61
引用
收藏
页码：A57 / A57
页数：1
相关论文
共 10 条
  • [1] Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism
    De Clercq, E
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (1-2): : 457 - 470
  • [2] Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: Action via a novel non-nucleosidic mechanism
    McGuigan, C
    Pathirana, RN
    Snoeck, R
    Andrei, G
    De Clercq, E
    Balzarini, J
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (07) : 1847 - 1851
  • [3] 4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors.: Structure-activity relationship and mechanism of antiviral action
    de Castro, Sonia
    Peromingo, M. Teresa
    Naesens, Lieve
    Andrei, Graciela
    Snoeck, Robert
    Balzarini, Jan
    Velazquez, Sonsoles
    Camarasa, Maria-Jose
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (18) : 5823 - 5832
  • [4] Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766):: in vitro and in vivo antiviral activity and mechanism of action
    Reefschlaeger, J
    Bender, W
    Hallenberger, S
    Weber, O
    Eckenberg, P
    Goldmann, S
    Haerter, M
    Buerger, I
    Trappe, J
    Herrington, JA
    Haebich, D
    Ruebsamen-Waigmann, H
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (06) : 757 - 767
  • [5] A new family of non-nucleoside inhibitors of human cytomegalovirus (HCMV) and varicella-zoster virus (VZV) based on the β-keto-γ-sultone template
    De Castro, S
    García-Aparicio, C
    Andrei, G
    Snoeck, R
    De Clercq, E
    Balzarini, J
    Camarasa, MJ
    Velazquez, S
    ANTIVIRAL RESEARCH, 2005, 65 (03) : A74 - A74
  • [6] From β-Amino-γ-Sultone to New Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Discovery of a Novel Class of HIV-1 Non-nucleoside Inhibitors
    Velazquez, Sonsoles
    De Castro, Sonia
    Balzarini, Jan
    Camarasa, Maria-Jose
    ANTIVIRAL RESEARCH, 2009, 82 (02) : A26 - A27
  • [7] Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCVNS5B polymerase with potent antiviral activity and a unique mechanism of action
    Shih, I-hung
    Vliegen, Inge
    Peng, Betty
    Yang, Huiling
    Paeshuyse, Jan
    Purstinger, Gerhard
    Fenaux, Martijn
    Mabery, Eric
    Bahador, Gina
    Lehman, Laura S.
    Bondy, Steven
    Tse, Winston
    Reiser, Hans
    Lee, William A.
    Neyts, Johan
    Zhong, Weidong
    HEPATOLOGY, 2007, 46 (04) : 859A - 859A
  • [8] Indolyl aryl Sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: Role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity
    La Regina, Giuseppe
    Coluccia, Antonio
    Piscitelli, Francesco
    Bergamini, Alberto
    Sinistro, Anna
    Cavazza, Antonella
    Maga, Giovanni
    Samuele, Alberta
    Zanoli, Samantha
    Novellino, Ettore
    Artico, Marino
    Silvestri, Romano
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (20) : 5034 - 5038
  • [9] A new class of tight binding non-nucleoside reverse transcriptase inhibitors inhibit the burst and steady-state phases of wild-type and Y188L HIV-1 reverse transcriptase activity
    Leveque, V.
    Giannetti, Tony
    Li, Y.
    Deval, J.
    Harris, S.
    Cammack, N.
    Klumpp, K.
    ANTIVIRAL THERAPY, 2008, 13 (04) : A58 - A58
  • [10] Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs):: A new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors
    Arranz, ME
    Díaz, JA
    Ingate, ST
    Witvrouw, M
    Pannecouque, C
    Balzarini, J
    De Clercq, E
    Vega, S
    BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (12) : 2811 - 2822
1