Synthesis of new 4-aryl/alkyl-1-(5′,5′-diphenyl-4′-oxo-1′-H-4′,5′-dihydroimidazolidin-2′-yl)-3-hydroxy-1,2,4-triazolidine-5-thione derivatives as potential anti-cancer agents

被引：0
|
作者：
Datar, PA [1 ]
Shirodkar, PY [1 ]
Panikkar, KR [1 ]
机构：
[1] KM Kundnani Coll Pharm, Bombay 400018, Maharashtra, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2003年 / 42卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New 4-aryl/alkyl-1-(5',5'-diphenyl-4'-oxo- 1'H-4',5'-dihydroimidazolidin-2'-yl)-3-hydroxy-1,2,4-triazolidine-5-thiones 3 have been prepared by the reaction of 2-carbethoxy-(5',5'-diphenyl-4'-oxo-1'-H-4',5'-dihydroimidazolidin-2'-yl)-hydrazine 2 with various aryl/alkylisothiocyanates. Their anti-bacterial, anti-fungal, anthelmintic and anti-cancer activities are reported.
引用
收藏
页码：690 / 694
页数：5
相关论文
共 50 条
  • [21] Synthesis and bioassay of 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones as anti-cancer agents
    Bassam Abu Thaher
    Ihab Al-Masri
    Kanan Wahedy
    Rami Morjan
    Saeb Aliwaini
    Iman Mahmoud Al atter
    Aayat Ahmed Elmabhouh
    Areej khaled AL ibwaini
    Saba Luay Alkhaldi
    Basem Qeshta
    Claus Jacob
    Hans-Peter Deigner
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, 396 : 1797 - 1810
  • [22] Synthesis of 2-(4′-(3"-chlorobenzyloxy)-phenyl)-1,3,4-oxadiazolin-5-thione, 3-{4′-(3"-chlorobenzyloxy)-phenyl}-4-phenyl-1,2,4-triazolin-5-thione and their derivatives as potential antileishmanial agents
    Tiwari, R. K.
    Rastogi, Nisheeth
    Sethi, Ralkesh
    Varma, R. S.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 17 (02) : 177 - 182
  • [23] Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents
    Shah, Amish
    Raj, Dilipsinh
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2015, 19 (01) : 73 - 82
  • [24] 4-Allyl-3-[(5-methyl-2-oxo-1,3-benzox-azol-3-yl)methyl]-1H-1,2,4-triazole-5(4H)-thione
    Koeysal, Yavuz
    Isik, Samil
    Salgin, Umut
    Goekhan, Nesrin
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O2462 - U857
  • [25] SYNTHESIS OF [1,2,4]TRIAZOLO[3',4'-3,4][1,2,4]TRIAZINO[5,6-B]INDOLE, TETRAZOLO[5',1'-3,4][1,2,4]TRIAZINO[5,6-B]INDOLE AND THEIR DERIVATIVES
    YOUNES, MI
    ABBAS, HH
    METWALLY, SA
    ARCHIV DER PHARMAZIE, 1987, 320 (12) : 1191 - 1195
  • [26] SYNTHESIS OF 3,5'-DISUBSTITUTED 4-(2'-OXO-1',3'-BENZOXATHIOL-7'-YL)COUMARINS
    SRIHARI, K
    SUNDARAMURTHY, V
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1979, 18 (01): : 80 - 81
  • [27] SYNTHESIS OF NEW 2-ARYL-3,3A-DIHYDRO-4-OXO-5H-PYRAZOLO-[1,5-D][1,2,4]TRIAZINES AND SOME OF THEIR DERIVATIVES
    COUDERT, P
    MAVEL, S
    COUQUELET, J
    TRONCHE, P
    RUBAT, C
    BASTIDE, J
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (03) : 769 - 772
  • [28] 4-phenyl-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione
    Yildirim, SÖ
    Akkurt, M
    Çetin, A
    Cansiz, A
    Sekerci, M
    Kazak, C
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2005, 61 : O619 - O621
  • [29] SYNTHESIS OF [1,2,4]TRIAZOLO[3',4'-3,4][1,2,4]TRIAZINO[5,6-B]INDOLE DERIVATIVES AND 3-SUBSTITUTED 5-ETHYL-5H-1,2,4-TRIAZINO[5,6-B] INDOLE
    YOUNES, MI
    ABDELALIM, AA
    ABBAS, HH
    METWALLY, SA
    ARCHIV DER PHARMAZIE, 1987, 320 (12) : 1196 - 1202
  • [30] 3-(Adamantan-1-yl)-4-ethyl-1H-1,2,4-triazole-5(4H)-thione
    El-Emam, Ali A.
    El-Brollosy, Nasser R.
    Ghabbour, Hazem A.
    Quah, Ching Kheng
    Fun, Hoong-Kun
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1347 - +
12345