A novel and facile synthesis of 114,5-trisubstituted 1,2,3-triazoles from benzylic alcohols through a one-pot, three-component system

被引：18
|
作者：
Gonzalez-Calderon, Davir [1 ]
Santillan-Iniesta, Itzel [1 ]
Gonzalez-Gonzalez, Carlos A. [1 ]
Fuentes-Benites, Aydee [1 ]
Gonzalez-Romero, Carlos [1 ]
机构：
[1] Univ Autonoma Estado Mexico, Fac Quim, Dept Quim Organ, Toluca 50120, Estado De Mexic, Mexico
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 03期
关键词：
Triazoles; Diphenylphosphoryl azide; Benzylic alcohols; Azide-enolate cycloaddition; REGIOSELECTIVE SYNTHESIS; CLICK CHEMISTRY; 1,4,5-TRISUBSTITUTED 1,2,3-TRIAZOLES; ARYL AZIDES; CYCLOADDITION; DERIVATIVES; ROUTE;
D O I：
10.1016/j.tetlet.2014.12.019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple one-pot procedure has been developed to efficiently prepare 1,4,5-trisubstituted 1,2,3-triazoles from benzylic alcohols. The presence of diphenylphosphoryl azide (DPPA) and active ketones allows for an azide-enolate [3+2] cycloaddition by use of DBU. (C) 2014 Published by Elsevier Ltd.
引用
收藏
页码：514 / 516
页数：3
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