A straightforward and versatile approach to the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from alkyl halides via a one-pot, three-component reaction

被引：13

作者：

Gonzalez-Calderon, Davir ^{[1
]}

Aguirre-De Paz, Jose G. ^{[2
]}

Gonzalez-Gonzalez, Carlos A. ^{[1
]}

Fuentes-Benites, Aydee ^{[1
]}

Gonzalez-Romero, Carlos ^{[1
]}

机构：

[1] Univ Autonoma Estado Mexico, Fac Quim, Dept Quim Organ, Toluca 50120, Estado De Mexic, Mexico

[2] Univ Ixtlahuaca CUI, Ixtlahuaca De Rayon 50740, Estado De Mexic, Mexico

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 13期

关键词：

Triazoles; Alkyl halides; Azide-enolate cycloaddition; Dimroth cycloaddition; CLICK CHEMISTRY; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; TERMINAL ALKYNES; FACILE SYNTHESIS; BORONIC ACIDS; SODIUM-AZIDE; DERIVATIVES; SOLVENT; BENZYL; WATER;

D O I：

10.1016/j.tetlet.2015.02.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of 1,4,5-trisubstituted 1,2,3-triazoles by the coupling of three components (alkyl halides, sodium azide, and active ketones) through an azide-enolate [3+2] cycloaddition (Dimroth cycloaddition) has been developed for the first time. A wide variety of halides (including chlorides, bromides, and iodides as well as primary and secondary derivatives) have demonstrated the versatility of this method, which is based on a one-pot system under mild reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1713 / 1715

页数：3

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